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Calutide (Bicalutamide)

Calutide is a hormone-based chemotherapy. The NCI Drug Dictionary defines the compound as a “synthetic, nonsteroidal anti-androgen. Calutide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors.” Calutide is used in combination with other agonists like leuprolide or goserelin for the treatment of metastatic prostate cancer. It works by blocking the normal effect of the male hormone androgen. The main type of androgens produced by the body are testosterone and dihydrotestosterone (DHT). These are formed in testes, adrenal glands and tumors themselves, and they stimulate the growth of prostate cancer cells. Calutide blocks this ability in order to stop the growth and spread of cancer.

Other names for this medication:
Bicalutamide, Casodex, Bicalox, Bicalutamida, Bicusan, Bidrostat, Caluran, Calutide, Calutol, Capro, Cosudex, Imda, Lutamidal, Probic, Zolacos,

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Evidence of rare codon clusters within Escherichia coli coding regions. While human pluripotent stem cells are attractive sources for cell-replacement therapies, a major concern remains regarding their tumorigenic potential. A cross-sectional online survey including the Maslach Burnout Inventory was administered to Radiation Therapists in Australia.

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In unrelated CBT, HLA disparity is not a limiting factor and the incidence and the severity of acute and chronic GVHD is lower, even in the state of HLA 2 or 3 antigen-mismatched transplant, than in other stem cell transplantation, but the number of cells infused is important. However, despite being the most diverse plant family on Earth, the Orchidaceae lack a definitive fossil record and thus many aspects of their evolutionary history remain obscure. This paper reports a 21-year-old male with diffuse hair loss induced by sertraline use and improved by quitting the drug. While the structure of the complex is consistent with a great deal of the biochemical and biophysical data on fatty acid binding, it is not yet possible to provide a completely rigorous correlation between the structural and binding data.

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smoothness and surface porosity, were adjusted by the choice of calendering parameters. Melatonin, together with other free radical scavengers in the brain, reduces the free-radical damage caused by Al and A beta, except in the latter stages of the disease process. Microgranular cellulose improves dsRNA recovery from plant nucleic acid extracts. gondii can influence the transcription of HERVs in neuronal cells.

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Cytologic diagnosis of diseases of rabbits, guinea pigs, and rodents. The use of a continuous positive airway pressure (CPAP) device is often needed in order to maintain free breathing during the night and sometimes even during the day. Pharyngeal bolus transit was significantly faster than esophageal bolus transit. It was easily turned into various optically pure (S)-3-p-hydroxyphenyllactic acid derivatives. To investigate a difference with a comparable representative sample from the Danish population, we sent out an inclusion questionnaire to 3999 Danes in the age from 50 to 70 years randomly selected from the Central National Register.

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Tuberculous pleuritis was eventually diagnosed by thoracoscopic pleural biopsy. Statin-induced reduction of cell viability and apoptosis was measured by 3-(4,5-dimethylthiazol-2-yl)2,5 -diphenyl tetrazolium bromide (MTT) assay and caspase assay.

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Comparison between length of body axis of control and treated embryos clearly brings out the significant acceleration of development by excess insulin (0.175 to 17.5 nM). Several studies have evaluated clinical, histopathologic, cytogenetic, and molecular prognostic variables in uveal melanoma. However, these changes may not be BPD specific since similar changes were found in the clinical control group.

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The vascular response of the stomach to experimental alterations in the autonomic nervous system of the dog. The R230C ABCA1 variant is associated with type 2 diabetes, particularly of early onset, in the Mexican-Mestizo population. Randomized controlled trial comparing systematic depression treatment program with care as usual.

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If we depart from the fact, that many of the epilepsies have a secondary cause, with affective disorders associate, we can understand the most habitual association of anticonvulsant and antidepressant. Relational benefits of relational aggression: adaptive and maladaptive associations with adolescent friendship quality. Genotype/phenotype correlations in Arab patients with familial Mediterranean fever. TWENTY-FOUR HOUR KIDNEY STORAGE WITH REPORT OF A SUCCESSFUL CANINE AUTOTRANSPLANT AFTER TOTAL NEPHRECTOMY. Either a placebo (saline) or caerulein 0.6 microgram/kg was administered intramuscularly to volunteers at 23:00.

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Effect of phenobarbital on the altered biochemical phenotypes expressed by hyperplastic liver nodules during hepatocarcinogenesis in the rat. To describe the end-of-life symptoms of nursing home (NH) and residential care/assisted living (RC/AL) residents, compare staff and family symptom ratings, and compare how staff assess pain and dyspnea for cognitively impaired and cognitively intact residents.

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Their abundance is consistent with the suggestion that SAM:SMT is highly active in this organism and that the enzyme is an excellent anti-Pneumocystis drug target. Moreover, the expected positive relationship between CVM and complexity of HRV was found only in control group, thus indicating that CVM in women under therapy drop below a minimal value necessary to the association to become apparent, suggesting an unfavorable cardiac autonomic modulation in spite of HRT.

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Hypothalamic leptin gene therapy normalizes the mosaic skeletal phenotype of leptin-deficient ob/ob mice. First, gradient artifacts are caused by the switching of magnetic gradients during FMRI. CT and/or MRI documented bifrontal accentuated subdural hygromas and hematomas in 5 patients. Survival was compared with that in individually matched cancer cases derived from a pool of Italian cancer registries (the ITACARE data base). The aim of this study was to develop an in-vitro release method suitable for injectable slow-release lipid formulations of local anaesthetics (or other drugs).

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However, cells challenged after long-term (20-24 h) exposure to hemin (10 microM) were substantially more resistant than controls and were sensitized far less by Fe(HQ)2. Potential role of subunit c of F0F1-ATPase and subunit c of storage body in the mitochondrial permeability transition. In the mammalian retina, excitatory and inhibitory circuitries enable retinal ganglion cells (RGCs) to signal the occurrence of visual features to higher brain areas. Fra expression is detected in neurons just prior to and during axonogenesis in the embryonic ventral nerve cord of Aedes aegypti (dengue vector) and Anopheles gambiae (malaria vector). This lack of comprehensive inhibition of platelet function allows continued thrombus formation and exposes patients to risk for recurrent thrombotic events.

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Exercise-electrocardiography and/or pharmacological stress echocardiography for non-invasive risk stratification early after uncomplicated myocardial infarction. We found that onion is the optimal host for this species and populations grown on onion have maximum fecundity, longest adult longevity and reproduction period, and the shortest immature developmental time.

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Skin diseases among the retarded fall into four categories--common dermatoses, behavioral disorders, iatrogenic manifestations produced by drug therapy and a group of congenital, hereditary and unexplained cases. Acute cooling (from 37 to 17 degrees C) caused a reduction of the contractile response to norepinephrine in rat arteries, whereas those taken from ground squirrels maintained contractions at, or above, those attained at 37 degrees C. Urine samples from 41 patients with bladder Ca, 11 patients with history of bladder Ca but negative follow-up cystoscopy, 18 patients with benign prostate hyperplasia (BPH) and 15 normal healthy volunteers were assayed using an enzyme-linked immunosorbent assay for bFGF. Multivariate analysis demonstrated that heterozygosity for the CCR5-Delta32-bp variant is an independent prognostic factor for treatment outcome.

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With the new algorithm, it is possible to estimate the pose of a rigid body of which one or two markers are occluded in one of the images of the RSA radiograph with high accuracy as long as a proper MC-model of the markers in the rigid body is available. Time-density curves were then drawn for both kidneys and aorta using regions of interest (ROIs) or pixel-by-pixel analysis. (3,2)D GFT-NMR experiments for fast data collection from proteins.

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Protective role of endogenous nitric oxide to microcirculation of rats during burn shock Host susceptibility factors to bacterial infections in type 2 diabetes.

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It was demonstrated that reproducible, high-quality fMRI data can be obtained from alpha-chloralose anesthetized adult rat brain. On these dishes, and on smooth controls, primary PDLF and GF were seeded and assayed up to 14 days for proliferation, alkaline phosphatase (ALP) activity, and collagen content. The p40 subunit is also shared by the dimeric cytokines IL-12p40 homodimer and IL-23. Pregnancy and puerperium are most prevalent prothrombotic states leading to cerebral venous thrombosis.

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Idiopathic hypercalciuria is characterised by renal stone formation and vertebral osteoporosis. Curcumin attenuated the lipid peroxidation and apoptotic liver injury in copper-overloaded rats Recent studies suggest that in some circumstances, alcohol intoxication at the time of severe head injury may be neuroprotective. The implications of this arrangement of fibroblasts can be important to cardiac function.

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These results demonstrate that, in addition to mechanical factors in the environment of a joint, intrinsic genetic factors participate in the process leading to joint contracture. Based on the sequence information of Delta12-fatty acid desaturase genes (from Mucor circinelloides, Mortierella alpina, Mucor rouxii and Aspergillus nidulans), which were involved in the conversion from C18:1 to C18:2, a cDNA sequence putatively encoding a Delta12-fatty acid desaturase was isolated from Rhizopus arrhizus using the combination of reverse transcription-polymerase chain reaction (RT-PCR) and rapid amplification of cDNA ends (RACE) methods. The presence of hemodynamically significant coronary stenoses does not alter platelet reactivity but is associated with reduced platelet-neutrophil complexes in peripheral blood of patients with stable coronary artery disease.

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The objective of the present analysis was to identify differences in the vegetable variety in commercial vs. Onset of type 1 diabetes very early in life adds another dimension of risk, particularly affecting the acquisition of visuospatial skills.

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Acoustic rhinometry also provides a visual reflection of the nasal response to therapy, which may be useful in increasing compliance to prescribed medications. Particularly, cadmium (even at 10(-13) M) significantly suppressed TRAP activity, suggesting that this system is utilized as an acute biosensor for cadmium. 7KC has been shown to promote endothelial cell death and/or dysfunction, depending on its concentration. Carbohydrate mouth rinse does not affect performance during a 60-min running race in women. The effect of ETS to angina pectoris was suspected not to relieve anginal pain but also to reduce myocardial oxygen demand on exercise.

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Effects of kappa-opioid receptor stimulation on high glucose induced myocardial hypertrophy of neonatal rats We closed the giant omphalocele successfully by placing karaya gum sheets over it, which created a humidified environment and promoted natural skin epithelization over the skin defect. B4 recognized a complex receptor site for HIV on the T cell surface that includes CD4 and also may be influenced by interaction with HIV coreceptors.

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THE RADIOGRAPHIC DEMONSTRATION OF CYSTS AND ABSCESSES OF THE BRAIN. We also describe, for the first time, a successful outcome involving primary skin closure and daily irrigation of the wound with hydrogen peroxide. Strong stimulation of CBA lymphocytes in the mixed lymphocyte interaction with cells from the H-2-indentical strain C3H. German cockroach (GCr) allergens induce IgE responses and may cause asthma.

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To assess the impact of a multimodal educational outreach on physician screening and documentation of intimate partner violence (IPV) in primary care. The size of mesenchymal stem cells is a significant cause of vascular obstructions and stroke. Despite the reduction in the formation of low-molecular-weight murein turnover products, neither the rate of murein synthesis nor the amount of murein per cell was increased. Assessment of measuring circulating levels of interleukin-6, interleukin-8, C-reactive protein, soluble Fc gamma receptor type III, and mannose-binding protein in febrile children with cancer and neutropenia. Since these areas have been related to the sustained attention and working memory processes, results would suggest that combined caffeine and glucose could increase the efficiency of the attentional system.

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Smad6 also inhibits the phosphorylation of Smad1 that is induced by the bone morphogenetic protein type IB receptor. Pelvic arteriovenous malformation: an important differential diagnosis of a complex adnexal mass. Two dihydropyrrolizine alkaloid metabolites isolated from mouse hepatic microsomes in vitro. Polycystic ovary (Stein-Leventhal) syndrome: etiology, complications, and treatment. Inhibition of neutrophil adhesion holds the promise of interrupting idiopathic inflammation in a variety of diseases, but also can increase susceptibility to infection.

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This effect of pravastatin may result from a reduction both in the level of oxidative stress and in MMP activity in the heart. Arp2/3 complex inhibition prevents meiotic maturation in porcine oocytes.

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Upon TCR-mediated positive selection, developing thymocytes relocate within the thymus from the cortex to the medulla for further differentiation and selection. Superoxide anion scavenging properties of fluvastatin and its metabolites. This article describes state-of-the-art knowledge and novel insights in the role of inflammatory processes on several aspects of inflammation-related skeletal muscle pathology and offers new insights in therapeutic perspectives.

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To address this issue, we investigated the multiple single-unit activity dynamics in rat medial prefrontal cortex (mPFC) during a Y-maze working memory task. The administration methods of the positive control drugs TPA (2.5 micro g/kg, 3 times/week, percutaneously) and MNU (75 mg/kg, single intraperitoneal injection) were based on the protocol of the ILSI/HESI international collaborative study.

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Merging catalytic asymmetric acyl halide-aldehyde cyclocondensation (AAC) reactions with ensuing Grignard-mediated ring opening of the derived enantiomerically enriched beta-lactones is presented as a generally useful asymmetric synthesis of beta-disubstituted carboxylic acids. Metformin does not lead to any improvement in IVF/ICSI outcomes among patients with PCOS. Emissions of atomic oxygen (1304 angstroms), atomic carbon (1657 angstroms), and atomic hydrogen (1216 angstroms) from Comet Kohoutek were observed with ultraviolet cameras carried on a sounding rocket on 8 January 1974. The transcription methodology is not the best choice for detecting errors at this level, however, as this type of error can be difficult to perceive.

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Corneal endothelial cell density and morphology in Phramongkutklao Hospital. Endogenous NO and ROS generation in grape roots and leaves under CdCl2 stress These animal models will provide excellent tools for in vivo testing of molecular mechanisms. PTEN and p27Kip1 have a cooperative role on inhibition proliferation, modulation of cell cycle and inducing apoptosis in prostate cancer PC-3 cell As in this instance, the initial clinical presentation of this problem can often be non-specific, with localising symptoms occurring later.

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In this report we describe the first case of alveolar echinococcosis and leukemic malignant T-cell lymphoma in a dog presented to a general practice in the Netherlands. Modification of nonspecific bronchial reactivity in hypothyroid children under different regimens of substitutive opotherapy. This was a retrospective cohort study of 42,268 women who delivered vaginally with normal neonatal outcomes. In the present study, we demonstrated that an invertebrate can be repulsed or attracted by the same natural odour at the same time and that these behavioural responses are likely aimed at achieving different physiologically relevant goals.

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A common concern of prospective in vitro fertilization (IVF) patients is the effect of treatment on their weight. Congestive heart failure is a pervasive disease afflicting millions of people.

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The ratios of zinc to cadmium in sphalerites are similar to the ratios of zinc to cadmium in the whole coals from which the sphalerites were separated. EEG patterns and their relationship to other physiologic signals serve as templates for normal brain organization and maturation, subserving multiple interconnected neuronal networks. We feel that a more conservative approach to fractures involving a sinus is warranted.

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Interpretation of chromatographic behavior of ions based on the electric double-layer theory. Image data were analyzed in three steps after completion of all data acquisition.

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However, the cell wall and its stucture may interfere with the fluorescent signal recorded. Intensive glucose-lowering therapy reduces cardiovascular disease events in veterans affairs diabetes trial participants with lower calcified coronary atherosclerosis. cholerae chaperonins and those of the Haemophilus and Yersinia species. These data indicate that, exercise training, whether conducted concurrently or introduced during the course of a high-fat diet, is an asset to reduce the deleterious effects of a high-fat diet.

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These results suggest that unilateral hindpaw inflammation activates the coeruleospinal modulation system and that this modulation system is active not only at the lumbar segments but also at the cervical level where spinal segments are distant from the inflamed plantar region. Reforming the hospital service structure to improve efficiency: urban hospital specialization.

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A Southwest Oncology Group perspective on the Revised European-American Lymphoma classification. Difference in the effects of the different therapeutic approaches was investigated using the non-parametric Wilcoxon-Mann-Whitney test. Recent developments in magnetic resonance (MR) imaging of the heart have refocused attention on the potential of MR and continue to attract intense interest within the radiology and cardiology communities.

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Mutation analysis of the MEN1 tumour suppressor gene in malignant melanoma. Cell motility driven by actin polymerization is pivotal to the development and survival of organisms and individual cells. These tonic fibers undergo physiological changes during amplexus including a membrane potential shift in the direction of the mechanical threshold and greater efficiency of contraction. Face MI cold block also significantly affected the duration of some masticatory-related EMG activities and had some limited effects on the temporal relationships of the EMG activities during mastication. Identification of a new variable sequence in the P1 cytadhesin gene of Mycoplasma pneumoniae: evidence for the generation of antigenic variation by DNA recombination between repetitive sequences.

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First, when large numbers of B cells are recruited into antibody responses and plasmablasts outgrow the PDC stroma, only those associated with PDC survive and differentiate into plasma cells. Beta-blockers have the best evidence for efficacy and deserve more attention. The rationale for an acute heart failure syndromes clinical trials network.

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Oligomycin sensitivity conferral protein can be interchanged with the 26,500-dalton ATPase binding protein in the binding of the ATPase and the 32Pi-ATP exchange. Morphological sertraline 50 mg blue tablets steroids picture of tuberculous meningitis treated with streptomycin, with special reference to vascular changes Concomitant, electrophoretic mobility shift assay revealed that CsA selectively inhibits the cytokine-induced DNA binding of activator protein-1 and NF-kappaB.

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These results highlight the physical demands associated with posologie zeclar 250 ml collisions and tackles in professional rugby league. No effects on experimental anxiety were seen in the plus-maze following galanin injection.

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Efficacy with cryosurgery is variable, and is a modality for treating individual, visible lesions while failing to treat subclinical lesions. Importance dapoxetina usa of audiometric study in tumors of the cerebellopontile angle (neurinoma of the acoustic nerve) Any use of the specimens for research requires deidentification of the samples and must be approved by Institutional Review Boards. Prophenoloxidase (proPO) activation in Manduca sexta: an analysis of molecular interactions among proPO, proPO-activating proteinase-3, and a cofactor. Nor did storage of leukaemic chicken plasma at -70 degrees C and one thawing substantially influence the lengths of AMV RNA.

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The experimental aqueous solubility, log D and in vitro transdermal flux values were determined for these compounds. Using these results, we will assess the need to conduct larger and longer studies with similar design. Twenty consecutive patients (29 breasts) undergoing immediate breast reconstruction with tissue expanders had acellular dermal matrix augmentin 1 2 g iv stamp augmentation of the pectoralis major muscle.

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CYTOLOGIC FEATURES AND CELLULAR MIGRATION IN THE CORTEX AND MEDULLA OF THYMUS IN THE YOUNG ADULT RAT. Covered self-expanding stent treatment for anastomotic leakage: outcomes in esophagogastric and esophagojejunal anastomoses. This system allows a better understanding of the specific roles played by each of the follicle compartments during development. Furthermore, use of autophagy inhibitor 3-methyladenine (3-MA) blocked berberine-induced autophagy level, and abrogated the protection of berberine against heart hypertrophy, tablet nexpro forte cardiac dysfunction, and apoptosis.

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In the present study, we reported a case of fungus ball type pansinusitis from a 32-year-old woman in Iran. The contribution of Helicobacter pylori (HP) infection to the risk of myocardial omeprazole vs lansoprazole versus omeprazole 20 infarction was evaluated. CHS is a life-threatening disorder characterized by hypoventilation during sleep. Modification of collagen with a natural derived cross-linker, alginate dialdehyde. Dopaminergic fibers reside only at the surface of the acini next to the peripheral cells.

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By transient expression of CRE-reporter genes or GAL4-CREB fusion proteins, the present study shows that inhibition of CREB/CRE-directed transcription by cyclosporin A and FK506 occurs in a great variety of cell types including in cell lines derived from tissues in which adverse effects of the immunosuppressants develop. Several aspects of diagnosis and management of this tumour provide zindaclin 1 gel clindamicina fosfato de amonio a unique challenge to the clinician. CT and MRI imaging and histopathological characteristics of five patients with hepatic EHE were retrospectively reviewed and the correlation of their imaging characteristics with pathological findings was analyzed.

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ThermoSpot performed well when used by non-medically trained volunteers for the detection clindagel reviews acnepril of neonatal hypothermia in the homes of an urban slum community. Case report of an 11-year-old child with a nonfunctional malignant pheochromocytoma. Current drug treatments are able to lower circulating glucose but do not address the problem of glucose utilization in the intracellular milieu, the consequence of which is tissue damage.