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Duodart (Dutasteride)

Duodart is an aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, Duodart is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Duodart is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland. It has a role as an EC [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor and an antihyperplasia drug. It is an aza-steroid, a member of (trifluoromethyl)benzenes and a delta-lactam. It derives from a hydride of a 5alpha-androstane.

Other names for this medication:
Dutasteride, Deetor, Duodart, Duprost, Dutagen, Dutas, Dutasterida, Dute, Veltride,

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Prior stillbirth is a risk factor for stillbirth in a subsequent pregnancy. Circumstantial evidence indicated a human source of infection, human faecal material having been spread on the pasture grazed by the cattle. The inhibition was paralleled by a reduction in hyaluronan-dependent monocyte adhesion to the ECM.

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Fourteen focus group discussions were conducted with nurses in 2 university hospitals in Egypt. Structural organization of the human gamma-glutamyl hydrolase gene. Liver samples were obtained in a time-course manner, and changes in gene expression examined by an Affymetrix GeneChip. Antifungal prophylaxis with voriconazole or itraconazole in lung transplant recipients: hepatotoxicity and effectiveness. Computing the joint distribution of tree shape and tree distance for gene tree inference and recombination detection.

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Topology description for data distributions using a topology graph with divide-and-combine learning strategy. Other metals that do not interact with ascorbic acid had little effect on vitamin C transport.

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Furthermore, the magnitude of suppression was significantly associated with task performance across both groups. Sequence clusters in human immunodeficiency virus type 1 reverse transcriptase are associated with subsequent virological response to antiretroviral therapy.

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In mature apple fruits, where vacuoles occupy most of the cells, PPO was detected immunochemically near the cell walls with use of anti-apple PPO antibodies. Surgery was performed in two stages, the first consisting of a midline celiotomy, dissection of visceral/neural structures, and ligation of internal iliac vessels, followed by an anterior L5-S1 discectomy. Surgical options can almost always be delayed until fetal maturity is achieved and a simultaneous cesarean section can be performed.

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Behavioral and biochemical manifestations of mecamylamine-precipitated nicotine withdrawal in the rat: role of nicotinic receptors in the ventral tegmental area. Kinematic evaluation of cruciate-retaining total knee replacement patients during level walking: a comparison with the displacement-controlled ISO standard. These findings suggest that mechanisms mediated by brain noradrenergic alpha-receptor play an important role in muricide inhibition by tricyclic antidepressants in rats and that the medial amygdaloid nucleus is an important site of action of these drugs.

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This article is part of a Special Issue entitled Oxytocin and Social Behav. Draw the free end of this second loop into the joint and feed it into the first loop. Angiographic results after the use of a sutureless aortic connector for proximal vein graft anastomoses. Craniofacial tissue engineering and regeneration remain challenging problems for oral and maxillofacial surgeons and scientists.

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Despite its biological relevance, the intrinsic acid lability of phosphoarginine (pArg) has impaired studies of this novel PTM. These factors help explain the role of dysfunctional backgrounds in entry to prostitution without presupposing a role for unobservable traumas and psychiatric disturbances. The follow-up after the initial surgery ranged from 2.7 to 19.7 years (mean 8.5 years). We have previously shown that segmenting the surfaces by color, a ventral stream feature, did not affect repulsion but instead reduced the time needed to process both surfaces.

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The CaCTR1 gene is required for high-affinity iron uptake and is transcriptionally controlled by a copper-sensing transactivator encoded by CaMAC1. The juvenile toxicity study as a tool for a science-based risk assessment in the children population group. The efficacy and safety of this therapy concerning the development of chronic cerebral vasospasm were evaluated in a swine model.

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Telmisartan, a widely used AT1 receptor antagonist, inhibits the transport capacity of ABCG2 and may cause drug-drug interactions, especially in individuals carrying polymorphism that facilitate the telmisartan-ABCG2 interaction. Mapping of MS/MS sequenced peptides to the precursor highlighted three atypical monobasic processing sites, including the established C-terminus of ghrelin and the N-terminal cleavage site for obestatin, a putative 23-amino-acid C-terminally amidated peptide. Current management of intracranial aneurysms is a merge between derived knowledge of early generational concepts and current technology.

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Cloning and characterization of Ehox, a novel homeobox gene essential for embryonic stem cell differentiation. To elucidate one of the mechanisms of antibiotic tolerance, the present study investigated the role of Pseudomonas aeruginosa quorum sensing (QS) and the rpoS gene in antibiotic tolerance.

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The patient died during the postoperative period due to prolonged haemorrhagic shock and developing multiorgan failure. T2-weighted MR images of the brain showed patchy areas of high signal intensity in the cerebral white matter. Renally mediated hypertension involves the activation of RAAS leading to angiotensin II-mediated vaso-constriction, and aldosterone-mediated salt retention.

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This study indicated the feasibility of a hand-held detection system in the localization of cervical cancer after injection of (111)In-labeled MAb Cx-99. Two groups of ten cattle were each inoculated with pools of brain material from sheep scrapie cases collected prior to 1975 and after 1990. We examined the prevalence of suicidal ideation, the incidence of attempted suicide, and the extent of service utilization following attempted suicide among representative samples of White, Irish, Black Caribbean, Bangladeshi, Indian and Pakistani individuals living in England.

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Screening for beryllium disease among construction trade workers at Department of Energy nuclear sites. Increased experience with the use of reteplase in the treatment of acute lower extremity occlusions is accumulating. Local elasticity imaging of vulnerable atherosclerotic coronary plaques. A 64-year-old male with renal cell carcinoma metastatic to bone, skin, lung, and the central nervous system presented for IL-2/TIL treatment.

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Additional benefits may be obtained by adding sensory awareness-directed physiotherapy aimed at changing painful muscle tensions, body attitude, movement pattern and dysfunctional respiration pattern. An outstanding challenge is the extension of the results achieved for static networks to time-varying networks, where the topological structure of the system and the temporal activity patterns of its components are intertwined. Clinical and endoscopic examination and radiography performed 4 times during the following 2 years showed no evidence of recurrence.

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A comparison of the age of onset of bipolar I and bipolar II outpatients. Using Ras-transformed rat intestinal epithelial cells (Ras12V cells) as a model, we have begun identifying the RBPs that associate with the ODC transcript. Furthermore, Mo uptake by MOT1 in yeast was not affected by coexistent sulfate, and MOT1 did not complement a sulfate transporter-deficient yeast mutant strain.

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MAP-DNA interactions also show weak preference for AT-rich fractions, and are sensitive to S1 nuclease digestion. Recent work with plants has demonstrated that genome instability can be triggered by a change in chromosome number arising from either whole genome duplications (polyploidy) or loss/gain of individual chromosomes (aneuploidy). Nonsurgical therapy to preserve oviduct function in patients with tubal pregnancies. A METHOD FOR EXACT INTRACELLULAR LOCALIZATION OF TRITIATED SEX HORMONES BY AUTORADIOGRAPHY. Effect of clinical mastitis on the lactation curve: a mixed model estimation using daily milk weights.

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CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus. Differentiation of the activated neural stem cells was also investigated by co-expression of neuronal/glial cell markers (GFAP, Neu N and CC-1).

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Comparisons between SA cases versus those without SA revealed in the former group significantly increased connectivity with regions modulating the response to stimuli independently to their potentiality of threat (prefrontal, primary and somatosensory association, superolateral and medial-inferior temporal, xorox team online tool v2.8 associative and secondary occipital ones). The average age at onset of the first keratitis preceding surgery was 18 years (between 5 and 40 years). There is increasing pressure, with strong support from consumers, that some level of communication skills competency should be imposed by the licensing authorities. We examined 1 022 men and women, aged 30-79 years, who participated in a health screening test.

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The main outcome measurements were time intervals and total time intervals that considered the numbers of simultaneously engaged workers and were calculated as the product of time intervals and the number of workers, and the labor cost of individual components of each procedure. Given that the Internet could represent a worker education and empowerment tool, and considering the increase in popularity of silicosis-related information, we aimed at systematically analyzing the reliability and readability of online silicosis-relevant information. The responses to acetylcholine were potentiated by cocaine (greater than 10(-6) M) and inhibited seroplex 5 mg gouttes na by phentolamine (10(-6) M). Implications of high-risk family studies for prevention of depression.

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Disadvantages of NLBB include vasovagal episodes, patient discomfort, and miss rates. We also examined the effect of venlafaxine missed 2 doses exogenous glutamine on evoked and spontaneous activity and found that addition of physiological concentrations of glutamine to perfusate of slices isolated from injured cortex increased the incidence and decreased the refractory period of epileptiform potentials. Preoperative, intraoperative and interval postoperative TCD monitoring of the middle cerebral artery (MCA) ipsilateral to the operated carotid artery.

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The susceptibilities were examined using Bordetella pertussis IgG ELISA. Laparoscopic cytoreductive surgery and early postoperative intraperitoneal chemotherapy for patients with colorectal cancer peritoneal carcinomatosis: initial results from a single center. We review the physiology of bladder cooling response in experimental animals and humans, and present its clinical usefulness. These include 1) word normalization, 2) word completion, 3) target terminology specification, 4) spelling correction, 5) lexical matching, 6) term completion, 7) semantic locality, 8) term composition and 9) augmentin syrup children decomposition. Expression of mRNA for endothelin-1 and its receptors in rat kidney after burn injury

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Emphasis is directed at treatment modalities and the utility of chelators in attenuating the neurodegenerative sequelae of exposure omeprazole 40 mg mylan to Mn. The change of the spinal evoked potential caused by constant-speed subacute compression of the spinal cord These cells were cultured for one to eight passages (each passage lasting about 3 days) in monolayer culture. Vegetal or animal food can produce hipersensibility reactions IgE mediated of diverse intensity. The GMCs against most pneumococcal serotypes were substantially higher than described with the same or other pneumococcal conjugate vaccines in other populations.