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A phase I/II clinical trial of enzyme replacement therapy in mucopolysaccharidosis II (Hunter syndrome). Based on effectiveness and tolerability data, therapy has a significant effect in patients with compensated cirrhosis, while decompensated patients need to weigh the risks versus benefits of treatment. Endosonography (EUS) is the most accurate modality for assessing depth of tumor invasion and local lymph node metastasis. Similarly, an injection of either saccharated iron oxide or Thorotrast lowered liver tryptophan pyrrolase activity more extensively in normal than in tolerant animals. Epistasic studies position it downstream of the apical protease ModSP and upstream of the terminal protease Spaetzle-processing enzyme.

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The present review outlines the clinical potential of magnetic resonance (MR) spectroscopy of the heart. We present a modified technique for the reconstruction of the intervalvular fibrous body in double-valve replacement through an aorto-annulo-atriotomy. Fifty-eight adults with CVID receiving IVIG therapy completed the Medical Outcomes Study 36-Item Short-Form Health Survey to evaluate their HRQOL and were compared with DM and CHF patients. Enhanced dielectric polarization and electro-responsive characteristic of graphene oxide-wrapped titania microspheres.

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Fabrication of high-reflectivity superimposed multiple-fiber Bragg gratings with unequal wavelength spacing. A retrospective review of medical records of patients who underwent RARC with intracorporeal neobladder performed by one surgeon (G.-P.H.) at our tertiary center from January 2012 to February 2015 in which at least one additional maneuver was required beyond preservation of urethral length, removal of the sigmoid colon from the pelvis, and careful ileal loop selection.

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Accuracy of cytologic diagnosis of central nervous system tumours in crush preparation. In this article we describe the seed-filling acceleration technique and propose two fast reseeding processes that may be performed for each frame.

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If acid aspiration prophylaxis was used, further questions were asked relating to subgroups of patients, category, dose and route of administration of drugs used and whether there was an anticipated change in practice. There was a nonlinear dose-dependent association between body mass index and the risk of gestational diabetes, pre-eclampsia, and gestational hypertension, and the risk was increased already among normal weight primiparae women. Adolescence is characterized by drastic behavioral adaptations and comprises a particularly vulnerable period for the emergence of various psychiatric disorders. Indirect multi-trophic interactions mediated by induced plant resistance: impact of caterpillar feeding on aphid parasitoids. The diseases are a diverse lot, owing to the wide range of skin structures and large surface area.

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Powerful graft-versus-leukemia effects exerted by HLA-haploidentical grafts engrafted with a reduced-intensity regimen for relapse following myeloablative HLA-matched transplantation. Protective effect of rhBNP on intestinal injury in the canine models of sepsis. This study provides evidence that network (in)efficiency might drive the association between SVD and cognitive performance. Considerable energy throughout development of the FMCR was devoted to obtaining input from potential end-user audiences through an active dissemination effort. PHYB1 and PHYB2 regulate elongation of sheath and stem tissues of mature plants and contribute to the light-mediated regulation of PhyA and Cab gene transcripts.

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Correlation between the intensity of in vitro migration of peritoneal exudate cells and the quantity of nonadherent cells. Endothelial-dependent vasodilation was similar in arteries from nonpregnant heterozygous and wild-type mice. The effects of administrative interventions on the specific time intervals were assessed.

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T lymphocytes and macrophages, but not motile spermatozoa, are a significant source of human immunodeficiency virus in semen. GSK3beta plays a pivotal role in the regulation of numerous cellular functions (including phosphorylation) and, thereby, regulation of many metabolic, signaling, and structural proteins as well as transcription factors that can influence cell survival.

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Characterisation of cellulose films regenerated from acetone/water coagulants. Complaints of cold extremities among patients on antihypertensive treatment. A total of 83 articles were selected from a systematic literature search and were included in the meta-analyses. A dynamic lumped parameter model of the left ventricular assisted circulation.

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Temporal lobe epilepsy associated with old intracerebral hemorrhage due to capillary telangiectasis in the temporal lobe: case report Here we identify MCH as the ligand for the orphan receptor SLC-1. Online nurse educators available for part-time teaching in BSN and RN-BSN courses. We conclude with a discussion of the clinical relevance of endocrine-immune investigations and thoughts about the next decade of endocrine research in PNI. The pro-apoptotic effect of NMDA was exhibited at early and late culture stages, whereas the anti-apoptotic effect was transient occurring on 7 DIV only.

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The time between injury and hospital admission proved to be another important prognostic factor. Our previous mouse experiment showed intraperitoneal administration of CPT-11 was more effective not only for peritoneal seeding but for liver metastases than intravenous administration of CPT-11. A discrepancy in the measured and forward and reverse fluxes in this reaction has been attributed previously to the participation of the gamma-phosphate of ATP in other exchange reactions. In contrast, the source amplitudes of the 600 Hz oscillations remained stable across all stimulus rates. Appropriateness criteria scores and demographics were also obtained.

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However, our study has shown clearly that high-dose paclitaxel can be safely incorporated to dose-dense sequential chemotherapy. Conventional Doppler echocardiography and TDI of the mitral and tricuspid annulus were performed.

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In addition, we assessed clinical use of antitissue transglutaminase values to predict biopsy results. The results obtained were compared to the predictions and findings as delivered by molecular modeling.

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A mature, functional arteriovenous (AV) access is the lifeline for a hemodialysis (HD) patient as it provides sufficient enough blood flow for adequate dialysis. Analgesia-based sedation with remifentanil was very effective, well tolerated and had a similar adverse event and haemodynamic profile to those of hypnotic-based regimens when used in critically ill neuro-intensive care unit patients for up to 5 days. Genomic variability in Mexican chicken population using copy number variants. We also estimated the magnitude of the nonlinear coefficients involved. Immunofluorescence microscopy was used to detect the expression of Cx43 on the induced cells.

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Pyelovenous fistula revealed by repeated thromboembolic events after emergency peripartum hysterectomy Age-standardised cancer incidence rates in reproductive system, digestive system and respiratory system were analyzed taking into account the statistics for 38 States of USA (1996-2001), European Union (2006) and Europe (2006).

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Recent data suggest a role for MMPs in a number of renal pathophysiologies, both acute and chronic. TXA(2) (or mimetics) is a powerful constrictor of bronchial muscle in vitro and in vivo.Levels of TXB(2), a metabolite of TXA(2), increase in blood or bronchoalveolar lavage fluid after allergen challenge in atopic asthmatic patients.TXA(2) mimetics induce airway hyperresponsiveness to nonspecific stimuli such as acetylcholine or methacholine.TXA(2) synthetase inhibitors or TXA(2) receptor antagonists inhibit asthmatic responses or airway hyperresponsiveness in various animal models and in patients with asthma. Remarks on some pathologic and physiologic conditions of the human voice. This may contribute to its anti-inflammatory effect observed clinically.

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Finally, novel strategies which are based on an increased understanding of the brain mechanisms underlying OCD and which are under investigation will be reviewed. It is not known how plasma levels of these hormones respond to changes in cardiac function that occur as a result of treatment with angiotensin-converting enzyme (ACE) inhibitors. They were perivascular spaces distensions, probably caused by disorder of the permeability of the arterial wall.

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Water requirement of the grapevine in draught conditions in Central Asia Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death and new therapies are urgently required to treat this disease. Quasi-species complexity and diversity were evaluated in matched African American and white individuals. Therefore, in patients with acute dialysis-dependent myeloma cast nephropathy, in addition to chemotherapy, HDF with a heat sterilized high-flux polyphenylene HF dialyzer could offer an alternative to HCO dialysis for extracorporeal kappa reduction with lower albumin loss. Eighty-one subjects with CTD (47 inpatients and 34 outpatients) were evaluated with pulmonary function tests (PFT) and radiological investigations.

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The subchondral contour of the ulnar trochlear notch was digitised to obtain the 3D coordinates of its surface points. Subclass of IgG belonged to IgG1 (4F7 and 5G1) and IgG2b (3H5), respectively. Genesis of Hydrocarbons of Low Molecular Weight in Organic-Rich Aquatic Systems. The aim of this study was to describe the characteristics and results of patients admitted to an intermediate respiratory care unit (IRCU).

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In addition to loss of tumor suppressive function, tumor-associated mutant p53 proteins often gain new tumorigenic activities, termed gain-of-function of mutant p53. This hypothesis, although contrary to much of the literature surrounding complexity in physiology, was found to be correct-for our study. The goal of this study was to define the prognostic value of serum myoglobin in patients with non-ST-elevation acute coronary syndromes (ACS). Erratum to: clinical comparison of the effectiveness of 7- and 14-day intracanal medications in root canal disinfection and inflammatory cytokines.

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IgY, the egg yolk immunoglobulin, equivalent to the IgG from mammals, has been used in veterinary practice for passive immunisation against bacterial or viral infectious diseases. Multivariate models were used to calculate adjusted odds ratios (aOR) for factors associated with treatment decisions. Control point (CP) and intensity are the two basic features used separately for image registration in the literature.

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A brief summary is also provided of some other topics discussed in detail elsewhere in this issue, such as susceptibility testing, pharmacodynamics, and pharmacokinetics-pharmacodynamics parameters. Plants have two kinds of fructokinases (FRKs) that catalyze the key step of fructose phosphorylation, cytosolic and plastidic. DIETARY DEPRIVATION AND LIPOGENESIS IN A MODEL SEBACEOUS STRUCTURE.

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Resource loss and posttraumatic responses in Bedouin members of the Israeli Defense Forces. Dynamic changes in blood proteins and lipids in myocardial infarct Open neural tube defects are among the most common severely disabling birth defects. Patients with a venous thromboembolism diagnosis during induction therapy may potentially benefit from a temporary inferior vena cava filter before surgery to limit the risk of recurrent pulmonary embolism. Therefore, this protein represents a novel therapeutic target for improvement of chemotherapeutic efficacy and predictive biomarker for patient survival.

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This nonbiased survey indicates that the HPV community in healthy humans is much more complex than previously defined by widely used kits that are target selective for only a few high- and low-risk HPV types for cervical cancer. The potential impact of Corexit on the surface ocean carbon dynamics has remained largely unknown. These results underscore the importance of ensuring valid endpoints in automated claims databases. Bacteriodes fragilis group can inhibit the phagocytosis and killing of co-existing aerobes. Volumes reconstructed by standard methods from single-slice helical computed tomography (CT) data have been shown to have noise levels that are highly nonuniform relative to those in conventional CT.

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In experiment group, CBF increased together with the beginning of electrical stimulation. Methylated human gene biomarkers used in combination may be clinically useful for triage of women with HR-HPV infections. We applied HyperPrior to test two arrayCGH datasets and two gene expression datasets for both cancer classification and biomarker identification. Atypical adenomatous hyperplasia, adenocarcinoma and squamous cell carcinoma.

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Nuclear hormone receptor-dependent HBV replication is inhibited by hepatocyte nuclear factor 3 (HNF3). Nevertheless, postoperative bleomycin injection decreases and stabilizes tumor size, and thus may be considered as an option of treatment modalities in patients with predominantly cystic craniopharyngiomas. The optimal supply model of water and nitrogen for spring maize in Wuwei Oasis was 300 kg x hm(-2) of nitrogen application plus 34, 136, 68 and 102 mm of irrigation at seedling, jointing, heading and grain-filling stages, respectively.

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Seminomas with exclusive intertubular growth: a report of 12 clinically and grossly inconspicuous tumors. Further studies on the reaginic antibody in gamma-A-globulin preparations. The clinical response to systemic immunosuppression shows that an immunoinflammatory disorder supports the nephrotic syndrome. Significant correlations between tumor volumes, as obtained from our mapping, and known prognostic parameters such as preoperative serum levels of prostatic specific antigen, loss of differentiation, histological grade, lymph node metastasis, and margins were found.

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explored statin effects on plaque composition detected by intravascular ultrasound (IVUS). Increasing PA and decreasing SBM use should be an aim in general health behaviour promotion. Fine-tuning pharmacogenetics: paradigm for linking laboratory results to clinical action.

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Which are the most frequently used outcome instruments in studies on total ankle arthroplasty? We provided in the current study a detailed discussion of the clinical outcomes, auxiliary-managements used to achieve continence, and the UDS outcomes. 2-Silyl group effect on the reactivity of cyclopentane-1,3-diyls. Systemic lupus erythematosus: an independent risk factor for endothelial dysfunction in women. Double refraction in leukocytes of peripheral human blood in supravital staining with toluidine blue

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Esophagography and flexible esophagoscopy were performed once a month at the first, second, and third postoperatively month. The DNA polymerase from the archaebacterium Desulfurococcus strain Tok (D. Balancing benefits and harms in health care: new trial on albumin and saline should have been considered. Grading apical vertebral rotation without a computed tomography scan: a clinically relevant system based on the radiographic appearance of bilateral pedicle screws.

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Dysregulation of antioxidant mechanisms and overproduction of ROS not only promotes a fibrotic milieu but leads to mitochondrial dysfunction and further exacerbates kidney injury. Associations of Neighborhood and School Socioeconomic and Social Contexts With Body Mass Index Among Urban Preadolescent Students.

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Evidence indicates that noninvasive transitional-cell tumor of the ureter is amenable to local resection. Admission GCS score, trajectory of the missile track, APR to light, and patency of basal cisterns were significant determinants of outcome in civilian GSWH. The coding sequence of the RUNX2 gene from 31 CCD patients from 20 families was analyzed using molecular genetic methods including polymerase chain reaction and direct sequencing.

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These results indicate that factors affecting mammals and birds also interact in the regulation of secretion of prolactin and GH in lower vertebrate species. Device for preparing combinatorial libraries in powder metallurgy. Histopathology diagnosis of coeliac disease - clinicopathological correlation is key! How do altered signaling pathways affect diseases of development and differentiation such as cardiovascular disorders and aging itself? Transcatheter embolization should be the initial treatment of choice in splanchnic artery aneurysms and pseudoaneurysms.

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To observe the effect of Bushen Tiaojing Recipe (BTR) and Xiaoyao Pill (XYP) on the morphology and sex hormones secretion of adenohypophysis and ovaries in androgen-induced sterile rats (ASR). To elucidate the possible involvement of the nervous system in the regulation of pathophysiologic responses in patients with rheumatoid arthritis (RA), we examined the expression of peripheral nerves containing the neuropeptides calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) in RA synovium and their effects on RA synovial cell functions.

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Furthermore, a thorough understanding of the molecular events underlying the observed complex motility patterns will make these phenomena amenable for intervention, which might result in the identification of new types of immune modulating drugs. Outcome measures derived from the LOS tests included movement velocity (MV), maximum center of gravity (COG) excursion (ME), end point COG excursion (EE), and directional control (DC). Angiogenesis and vascular malformations: antiangiogenic drugs for treatment of gastrointestinal bleeding. Blinded retrospective review of perceptual voice and stroboscopic parameters for patients with early glottic cancer and controls. In addition, the anti-tumoral effect of NVP-LBH589 was studied in a chimeric mouse model.