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Plagerine (Clopidogrel)

Plagerine is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke. Plagerine is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease. It has been shown to be superior to aspirin in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin. Plagerine was granted FDA approval on 17 November 1997.

Other names for this medication:
Clopidogrel, Plavix, Anclog, Anlet, Antiplar, Artevil, Clavix, Clopicard, Clopilet, Clopivas, Deplatt, Diloxol, Duoplavin, Expansia, Farcet, Globel, Grepid, Iscover, Karum, Klopidogrel, Nabratin, Narutis, Nefazan, Noklot, Pidocar, Pidogrel, Pladex, Plagerine, Planor, Tisten, Troken, Trombex, Vaclo, Zyllt,

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Activation of the hypothalamo-pituitary-adrenal axis and the sympathetic nervous system plays a crucial role in brain-mediated immunodepression. Dilemmas and controversies within civilian and military organizations in the execution of humanitarian aid in Iraq: a review.

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Dephosphorylation also led to an average 2-fold increase in MS sensitivity that facilitated peptide sequencing. Development of an in vitro test battery for the estimation of acute human systemic toxicity: An outline of the EDIT project. Surprisingly however, the echocardiogram performed in both patients failed to reveal any regional or global wall motion abnormalities or even diastolic dysfunction and remained absolutely normal throughout their 3-month follow-up period. Overall, the results indicated that varying levels of both utterance length and temporal complexity function to modulate stuttering frequency in adult stuttering speakers.

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Regional reductions in sleep electroencephalography power in obstructive sleep apnea: a high-density EEG study. The aim of the study was to develop a model of intravital microscopy of the microcirculation of the rat knee joint capsule in acute inflammation with the help of confocal laser scanning microscopy (CLSM). In the fourth and sixth weeks, lipid metabolism and cell apoptosis were augmented, and the former might be associated with the enhanced expression of plin, acsl6, scd2, elovl3, etc. Myasthenia gravis is an autoimmune disease characterized by fluctuating muscle weakness.

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Permeability of iodinated and MR contrast media through two types of hemodialysis membrane. With increasing climate variability and attempts to make more marginal land arable, abiotic and biotic stresses will be managed over the coming decades by tapping into the genetic diversity of wild relatives of O. We successfully demonstrated that Cdx2 induced not only morphological but also functional absorptive enterocytes in the intestinal metaplastic mucosa in vivo.

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Despite substantial demographic differences between Europe and North America, EuroSCORE performs very well in the STS database, and can be recommended as a simple, additive risk stratification system on both sides of the Atlantic. These studies indicated that there are at least four copies of the AOX gene in Arabidopsis.

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Interferon-gamma and interleukin-4 differentially regulate ICAM-1 and VCAM-1 expression on human lung fibroblasts. Endoscopic repair of an anterior cranial fossa cerebrospinal fluid (CSF) fistula has gained widespread acceptance.

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This study highlights the changes and patterns of adverse transition among adolescents. Although the clinical effects of inhaled GCs vary, there are few data on the differences in the responsiveness of individuals to inhaled GCs. The results demonstrate that the effect of reactor geometry on the global shear stress was significant. In the experience of optimal presence, biologically and culturally determined cognitive processes are working in harmony--to focus all levels of the self on a significant situation in the external world, whether this is real or virtual. Mosquitoes generally are subject to both density-dependent reductions in survival and growth and to density-independent limitations on their population abundances.

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The mechanism of maintaining tolerance could be explained by development of splenic T suppressor cells. We show that with this information, one can calculate the sample size required for the pediatric trial. Dermatomycosis in a pet inland bearded dragon (Pogona vitticeps) caused by a Chrysosporium species related to Nannizziopsis vriesii.

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Serum thyroid hormone and high-density lipoprotein cholesterol levels decreased, and the triglyceride and low-density lipoprotein cholesterol levels increased. Our analysis suggests that the recruitment of SF2/ASF to nSBs is mediated by a direct interaction with satellite III transcripts and points to the second RNA-binding domain of the protein as the major determinant of this interaction. Heat stress induced a 4-5-fold increase in anti-Hsp90 antibody reactivity over that of the unstressed controls. Using a closed circuit respirometer, we investigated resting metabolic rate (RMR) of three species of Crocidurinae shrews: Suncus etruscus, Crocidura russula, and C. To identify components of processes controlling gene expression during its life cycle, the malarial genome--along with seven crown eukaryote group genomes--was queried with a reference set of transcription-associated proteins (TAPs).

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The fate of the distal aorta after repair of acute type A aortic dissection. Contribution of visual evoked potentials, electronystagmography and the blink reflex to the diagnosis of multiple sclerosis

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Deficiency in induction but not expression of LTP in hippocampal slices from young rats. Optical analysis of perfusion bioreactor cell concentration in an acoustic separator. Technetium-99m labelled red blood cell scintigraphy indicated hemorrhage from the ileum, and laparotomy was then carried out. Images were reviewed and 5 criteria of esophageal motility evaluated. Cloth drape fixation using transparent adhesive dressings for facial plastic surgery.

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Genomic and functional characterization of three new venom peptides from the scorpion Heterometrus spinifer. Gaining access to these mechanisms will reveal the process by which the nervous system handles novel sophisticated coordinate transformation tasks, thus highlighting possible avenues to create functional human-machine interfaces that can make that task much easier. Significance and management of disability among urban elderly residents in Brazil. Primary outcome was to compare neurodevelopmental outcome at two years in intracytoplasmic sperm injection (ICSI) conceived children versus matched controls.

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In this paper we rationalize the essential ingredients needed to control the residence time and provide a proof of principle based on atomistic simulations. Pituitary apoplexy, bilateral carotid vasospasm, and cerebral infarction in a 15-year-old boy. Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. Synchronous urinary bladder metastasis of chromophobe renal cell carcinoma.

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We have employed immediate exercise testing to evaluate a large, heterogeneous group of low-risk patients presenting with chest pain. The prevalence of adenomas at autopsy is compared with the incidence of colorectal carcinomas within a defined population in northern Norway. Endoplasmic reticulum (ER) stress induces a complex network of pathways collectively termed the unfolded protein response (UPR). First, to establish an optimal cut-off value for the percentage of aberrant lymphocytes, previously determined based on clinical observations, via reference ranges for aberrant T-cells in the duodenal mucosa of celiac disease patient and control groups.

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To assess three domains of emotion recognition in people with traumatic brain injury (TBI). Comprehensive analysis of glycosylphosphatidylinositol-anchored proteins in Candida albicans. Their mean age at first symptoms were 9 years (range 6-11 years). Origin of atypical cells in cancer and tumors from Phytomonas tumefaciens Plasma levels of HSP10, HSP60 and BiP were measured by immunoassay and related to other plasma measures of inflammation.

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Sequencing the two STR loci, D8S1179 and D13S317, from heterozygous samples that displayed disproportionate signals between alleles revealed a single nucleotide polymorphism (SNP) in each locus that was coincident with the primer annealing sites. Assessment of bone ingrowth potential of biomimetic hydroxyapatite and brushite coated porous E-beam structures. The diagnosis was confirmed by histopathologic examination, direct immunofluorescence, and immunologic findings. Hormones and the differentiation of type A spermatogonia in mouse cryptorchid testes incubated in vitro.

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Essay with interpretation of electrohysterographic data obtained on animals in clinical conditions Central focused convolutional neural networks: Developing a data-driven model for lung nodule segmentation. This prospective case-control study enrolled 18 children who presented with febrile seizures and 18 children who presented with a febrile illness without seizures. The presence of IgG against VCA in 5 CFA patients suggests local production of EBV-specific immunoglobulins.

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Prolongation of VAT, increasing in R-wave amplitude and ST segment elevation was shown at ischemic area. The use of inhibitors of prenylation has proven to be a useful tool in the activation of apoptotic pathways in tumor cell lines. This represents a 10- to 100-fold increase in potency and up to a 10-fold higher selectivity over previously reported compounds derived from cysteine (J.

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Our aim was (1) to verify whether MAPs led to a reduction in health resources, and (2) to analyze the consequences of health policies implemented. We therefore tested induction of a vir promoter by a variety of phenolic compounds in isogenic strains that express or lack virH1 and virH2. The number of bacteria in the lungs and spleen of mice given these five strains decreased immediately. Therefore, based on our strain driving strategy, novel guidelines toward the reasonable design of sulfide semiconductors with tunable photoluminescence properties are proposed.

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In the community-hospital setting, the clinical practices of cardiologists are more compatible with published treatment guidelines than the clinical practices of other physicians. We conducted computational simulations on the thermal effects of implantable magnetic stimulation in a brain model using finite-element analysis, by varying geometric parameters of planar spiral coils, and repetitive stimulation pulse patterns. Additional information is given on soil to fruit transfer of U, Th and Pb for apple and mandarin grown under intensive agricultural conditions.

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After exposure, the dogs were observed for health effects over their lifetime. Net present value with payback period was utilized to evaluate the efficiency of the health information systems. In contrast to other studies, we found no significant differences for any HLA class II allele tested in our study group. Fludarabine-based nonablative chemotherapy agents, using standard dose combinations, produce moderate myelosuppression but are sufficiently immunosuppressive to allow engraftment of an allogeneic hematopoietic transplant and generation of graft-versus-malignancy effects.

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The IR characteristics of the individual surface complexes were indicative of molecular symmetries of the PO(4) unit of C(3v), C(2v), and C(3v), respectively. Distinct domains within the human cytomegalovirus U(L)26 protein are important for wildtype viral replication and virion stability.

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Some properties of induced electric fields in cell culture media produced by vertical circularly polarized magnetic fields are examined. A hybrid collagen/hyaluronan membrane with specific bubble macrostructure was designed to serve as a synthetic dermal substitute.

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Furthermore, we observed cell type-dependent differences in trafficking of both vGPCRs between fibroblasts and epithelial cells. Two studies are reported where psychotherapists use one of three different technologies in semistructured initial interviews: paper and pen, iPad, or a computer.

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We demonstrate that the activation domain of p53 participates in KIX binding and provide evidence showing that this interaction is critical for p53 transactivation function. The purpose of this study was to investigate risk of lung cancer incidence in textile industry workers by the type of job and evaluate the relation between occupational textile dusts exposure and lung cancer risk in a cohort.

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Activation of palmityl-coA: carnitine palmityltransferase in livers from fasted, fat-fed, or diabetic rats. The risk of hospitalization for congestive heart failure among older adults.

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Treatment patterns for cancer in Western Australia: does being Indigenous make a difference? The ligation of the receptors triggers inflammatory response necessary for pathogen elimination and for the healing process. This analysis was undertaken to examine the impact of the TNM system on the pathologic staging of SCLC and to assess the new IASLC proposals in this subtype of lung cancer.

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Study on high-rate and low-rate metastatic large-cell lung cancer cell lines via differential display reverse transcript PCR This was a national cohort study of 2,460 patients with pT3 rectal adenocarcinoma, undergoing major surgery without preoperative radiotherapy from November 1993 to December 2002. Periosteal new bone formation in polyarteritis nodosa: a-hycid 10 gel a syndrome involving the lower extremities. The polyphenols quercetin and naringenin also stimulated CRE-mediated gene transcription, but not in the range of resveratrol. Three-quarters of the respondents preferred to live in a village than in a city.

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