Silenor has been among the sedating antidepressants that for many years have been prescribed on an off-label basis specifically for the treatment of insomnia. Silenor originally was approved by the FDA for the treatment of depression in 1969. Although typically prescribed in antidepressant doses from 75 mg to 300 mg, it has been available in pill formulations ranging from 10 mg to 150 mg. The rationale for using Silenor to treat insomnia rests with the compound’s very high selectivity for an antihistaminic effect, thereby minimizing undesired side effects from other receptor interactions at low doses. In recent years, 1-, 3-, and 6-mg doses of Silenor have been investigated for the treatment of insomnia in randomized, placebo-controlled studies with insomnia subjects. These low doses were found to be well tolerated and they promoted both subjective and objective improvements in sleep throughout the night. The most prominent effects were on sleep maintenance with benefits persisting to the last hour of the night. In 2010, the FDA approved 3 mg and 6 mg Silenor tablets for the treatment of insomnia characterized by difficulties with sleep maintenance.
Other names for this medication:
Doxepin,
Sinequan,
Adapin,
Anten,
Aponal,
Deptran,
Doneurin,
Doxal,
Doxin,
Expan,
Gilex,
Mareen,
Quitaxon,
Silenor,
Sinepin,
Zonalon,
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Tamsudil,
Pulna,
Topzole,
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