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Topamac (Topiramate)

Topamac is a medication that has been available for a long time to treat migraines and seizures. Based on new research findings, Topamac is now being used “off-label,” or outside of its currently approved indications, to treat alcohol dependence. Specific circumstances, which your physician will discuss with you, may make this medication the first-choice treatment option. Exactly how Topamac works in alcohol dependence is not known, but it is thought to reduce alcohol’s pleasurable effects and so helps people to abstain from alcohol.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Response of the periodontium, pulp, and salivary glands to gingival and tooth injury in young adult male rats. Furthermore, silencing mlk3 prevented serum-stimulated cell proliferation and the proliferation of tumour cells bearing either oncogenic Ki-Ras or loss-of-function neurofibromatosis-1 (NF1) or NF2 mutations.

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A movie of left atrium (LA) with SEC in a patient with atrial fibrillation was recorded by TEE with the frequency range of 4-7.5 MHz. Recent studies have shown that metoclopramide may decrease postoperative narcotic requirements in patients undergoing second-trimester induced abortions or prosthetic hip surgery.

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Correlation analyses were performed between F-18 FDG PET/CT parameters and thyroglobulin (TG) level, and predictive factors for short-term progression were analyzed by logistic regression and receiver operating characteristic curve analysis. Institutionalizing faculty development is proposed in a description of a four-phase model. Transactivation and expression patterns of Jun and Fos/AP-1 super-family proteins in human oral cancer. Chemokines and chemokine receptors in the pathogenesis of systemic sclerosis.

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Emergency physicians should be aware of the potential for mistaking an interstitial pregnancy for an intrauterine pregnancy. Several pieces of evidence support a role for this protein in post-replicative MMR. We studied 92 adult pelvic CT scans and found significant gender differences in bony pelvic geometry, including acetabular socket depth and femoral head width. The development of oral candidosis in insulin-treated diabetes mellitus patients is not the result of a single entity, but rather, a combination of risk factors. The simulation results pointed out specific methodological challenges that need to be addressed before a practical implementation of OPET-based bioluminescence tomography is achieved.

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The purpose of this paper is to discuss the basic study of mechanism of brain injury analytically and experimentally, in respect to the frequency analysis of the pressure changes. Teaching critical appraisal: a pilot randomized controlled outcomes trial in undergraduate osteopathic medical education.

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In this study, we examined the ability of these antisera to neutralize the neurotoxicity of Crotalus durissus terrificus and Bothrops jararacussu venoms and their major toxins, cdt-crotoxin and bothropstoxin-I (BthTX-I), respectively, in mouse isolated phrenic nerve-diaphragm preparations. The psychological aspects of MG can be attributed to the expected consequences of a chronic but unpredictable neuromuscular disease involving weakness of breathing, swallowing, talking, limb and eye movement. Publishers and authors should strive to enhance the quality and quantity of data available in indexing services.

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Disruption of 14-3-3 binding at CR2 did not recover binding of Raf-1 to (V12,G37)Ras but allowed more efficient recruitment of Raf-1 to the plasma membrane and stimulated its phosphorylation on S338. 46 relatives of individuals suffering from schizophrenia were questioned by means of a problem-centred interview. Good anatomic and visual success can be achieved and maintained in CMV-related RD without the use of silicone oil. A series of biochip readers developed for gel-based biochips includes three imaging models and a novel nonimaging biochip scanner. We define two types of RNA transport structures in neurons, transport particles and RNA granules and distinguish them by the presence or absence of ribosomes.

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Among all other properties of NPs/NSs, as shown by various researchers, the size is an important parameter in the fate of the particle. Recently, however, it was learned that many patients with idiopathic chronic pancreatitis have mutations of the cystic fibrosis gene.

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The mass profile suggested the presence of additional peptides the majority of which consisted of eight to ten amino acid residues. Fusion or stability in the temporary fixation was evaluated on radiographs taken at 3, 6, 12 weeks and 6 and 12 months after the surgery. In the pilot study the authors refer to the possible connection between the appearance of keratoconjunctivitis sicca (KCS) and Chlamydia pneumoniae (CP) infection. alpha-Dystroglycan is one of the O-mannosylated proteins and is a central component of the dystrophin-glycoprotein complex that has been shown to be related to the onset of muscular dystrophy.

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Perioperative oral beta-blockade can reduce the frequency of atrial fibrillation without serious side effects. The proteins in blood and blister liquid of pemphigus and other bullous diseases. Immunohistochemical study using SP technique for CD40 was carried out. Systemic capillary permeability was evaluated by transcapillary escape rate of albumin (TERalb) (ie, the 1-h decline rate of intravenous (125)I-albumin).

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All patients with hemiplegia and able-bodied controls walked at self-selected speed over a 10-m walkway, either with or without an arm sling. Ampicillin and penicillin concentration in serum and pleural fluid of hospitalized children with community-acquired pneumonia. Specific environmental exposures within day care, such as the presence of pets or having a rug or carpet in the area where children sleep, may increase the risk of recurrent ear infections in the first year of life among children with familial history of atopy who attend day care. The application of calcium chelating agents (EDTA or EGTA) to the tips of maize roots caused a loss of gravitropic sensitivity. The same approach could be applied in other clinical settings such as primary care.

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Clinical significance of infection with the so-called enteric viruses We believe colonic transit time measurement is helpful to tailor therapy because it helps define the pathogenesis of constipation. The expression of SDF-1alpha mRNA in lymph node stromal cells obtained from patients with NHL was decreased after treatment by triptolide at concentrations of 25 and 50 nmol/L for 24 h. Low Molecular Weight Heparin use in Internal Medicine hospitalized patients

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Implications of the findings for research and practice are discussed. Forming the First Stars in the Universe: The Fragmentation of Primordial Gas. Moreover, all the beneficial effects of cyclo-dPAKKR in EAN are abrogated in p75NTR heterozygous mice, strongly suggesting a p75NTR-dependent effect. We established a real-time PCR assay on blood for the diagnosis and differentiation of the causative Candida species.

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Suppression of p53 functions during tetraploidization, either by RNA interference or by using p53-deficient mouse fibroblasts, produced cells that were chromosomally unstable. For some drugs, this results in rapid onset of action via a more comfortable and convenient delivery route than the intravenous route. Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase. IgE anti Hepatitis B virus surface antigen antibodies detected in serum from inner city asthmatic and non asthmatic children. The center of the lens is localized by horizontal and vertical intensity profile clustering and the lens contour is estimated by fitting an ellipse.

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Suppressive effect of glutamic acid decarboxylase 65-specific autoimmune B lymphocytes on processing of T cell determinants located within the antibody epitope. Fluctuations in ovarian steroid hormones affect the excitability of the visual system.

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Pancreatic ductal adenocarcinoma is a common malignancy of the gastrointestinal tract. Treatment with the peptide LALF(32-51) ameliorated the sepsis-induced effects in the lung and liver and increased the survival of mice in a dose- and time-dependent manner.

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Approximations made with the DLCA model, when combined with experimental kinetics and cell concentration results, not only allow us to quantify cell differentiation by a pseudo diffusion coefficient, but also measure the effects of tumor angiogenic factors (TAFs) on the formation of cord-like structures by ECs. This study was a retrospective analysis of a consecutive group of patients less than 20 kg weight, who underwent a thoracoscopy between 1998 and 2005. A retrospective review of 255 morbidly obese patients undergoing LRYGBP between March 2000 and February 2003 was conducted. Finally, the review presents the available clinical evidence for coronary microembolization in patients, highlights its key features--arrhythmias, contractile dysfunction, microinfarcts and reduced coronary reserve--, compares these features to those of the experimental model and addresses its prevention by mechanical protection devices and glycoprotein IIb/IIIa antagonism.

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Inferring biological functions and associated transcriptional regulators using gene set expression coherence analysis. In addition, TGF-beta1 expression within alpha-SMA or nestin expressing astrocytes was also detected.

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Sequences of EF-1alpha and 28S rRNA genes were analyzed under maximum parsimony with bootstrapping, and Bayesian methods to recover the best estimate of phylogeny. High resolution quantum cascade laser spectroscopy of the simplest Criegee intermediate, CH2OO, between 1273 cm-1 and 1290 cm-1. Mammographic density (MD) is one of the strongest breast cancer risk factors. The timing of antibody rescue in the mouse intoxication models revealed windows of opportunity for antibody therapeutic treatment that correlated well with the biologic half-life of the toxin in the serum.

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The role of aminopeptidases in larval metabolism and as potential targets for blowfly control agents is examined. Mutations of key basic residues within the NSE1/NSE3/NSE4 DNA-binding surface reduce binding to DNA in vitro.

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A qualitative model is proposed to account for the observed behavior. These results further our understanding of neutralization targets for primary, R5 HIV-1 viruses and demonstrate the utility of the XenoMouse system for identifying new and interesting epitopes on HIV-1. Altered developmental changes of neuromuscular junction in hypo- and hyperthyroid rats. To correlate cardiovascular magnetic resonance (CMR)-based measurement of aortic pulse wave velocity (PWV) with serum markers for atherosclerosis and plaque burden in the thoracic aorta.

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At the embryonic stages the adenylate cyclase of chick skeletal muscle possesses high catalytic activity, which is about 10 times higher than its mature level. Docetaxel as single-agent therapy in metastatic breast cancer: clinical efficacy.

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Elevation of intracellular cAMP levels with pentoxifylline, clenbuterol and rolipram also inhibited IC-induced activation of respiratory burst activity in equine PMN. Primary cultures of mammary tissue from ewes and goats were infected with the CAEV Cork strain. Review of their early symptoms and signs showed that there had been delays in diagnosis, ranging from a few months to many years.

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This study compared the efficacy of a single injection of NASHA with placebo in patients with osteoarthritis (OA) of the knee. Two arms with FOLFIRI, with or without cetuximab, were initially included in the randomized phase III intergroup clinical trial NCCTG (North Central Cancer Treatment Group) N0147. While a number of studies have investigated transmitter outflow in anesthetized animals after middle cerebral artery occlusion (MCAO) performed by craniectomy, studies have never been performed after MCAO induced by intraluminal filament. Patients anaesthetized with remifentanil and propofol have less postoperative nausea.

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vivax isolates from different endemic areas may be a useful alternative approach to establish the epidemiology of drug-resistant malaria. The implications of this finding for discerning the effects of neural plasticity over and above normal brain maturational processes are discussed. Review of publication bias in studies on publication bias: mandatory publication of data may help.

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Complementarity and competitiveness of the intrinsic and extrinsic components of the total ventricular load: demonstration after valve replacement in aortic stenosis. The aim of this study was to evaluate the roles of contrast-enhanced dynamic and static magnetic resonance imaging (MRI) and mianserin renal dose augmentin quantitative 99Tcm-labelled nanocolloid (NC) scintigraphy in detecting wrist joint inflammation in early rheumatoid arthritis (RA) patients. The present study enrolled 26 kidney transplant recipients receiving EC-MPS as part of their immunosuppressive therapy. Pharmacokinetics and drug-drug interactions of antiretrovirals: an update.

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