Topictal is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Topictal antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.
Other names for this medication:
Topiramate,
Topamax,
Epitomax,
Letop,
Neutop,
Piramax,
Talopam,
Topamac,
Topictal,
Topigen,
Topilex,
Topimax,
Topina,
Topiramato,
Topirol,
Toplep,
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Ranitidina,
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Veniz,
Nortriptilina,
Buspirone,
Deworm,
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Olit,
Zepoxin,
Amimox,
Bactrim,
Adiva,
Acyl,
Cefzon,
Natravox,
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