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Topictal (Topiramate)
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Topiramate

Topictal is a sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, Topictal antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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In the case of a superlattice (SL) structure, due to the mini-gaps induced by the SL geometry, some additional resonant peaks and valleys can be observed in the transmission spectra, and similar characters are also reflected in the conductance spectra. The results lend further support to the hypothesis that normorphine and the enkephalins activate preferentially mu-opiate receptors on the ileum, whereas dynorphin interacts predominantly at k-opiate sites.

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Screening for abdominal aortic aneurysm during transthoracic echocardiography in a hypertensive patient population. Pellets containing carbamyl-PAF (cPAF) were implanted in corneas of wild-type or PAF-receptor (PAF-R)-knockout mice, and the progression of angiogenesis was monitored by microscope. Radioimmunoassay was used to determine changes of cGMP in HTMCs. Tweet reach: a research protocol for using Twitter to increase information exchange in people with communication disabilities.

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Informative value of immunologic analysis of blood and ejaculate in diagnosing chronic prostatitis A dynamic pattern of EphA4expression occurs during shark fin development, suggesting an early role in outgrowth and patterning of the fin buds and a later role in tissue differentiation. A variety of drugs used in clinical practice may cause myopathy or interfere with neuromuscular transmission. Re: testosterone therapy during exercise rehabilitation in male patients with chronic heart failure who have low testosterone status: a double-blind randomized controlled feasibility study. Evaluation of dinaciclib in combination with other agents for other indications including breast cancer and multiple myeloma is in progress.

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Donor antigen expression promotes the accumulation of infiltrating cells in the graft and the development of donor specific alloantibodies. From experiments with computer-simulated and clinical Doppler ultrasound signals, it is shown that features extracted from the PCA method achieve better classification performance than those of traditional methods. Inflammation and gene expression in the rat lung after instillation of silica nanoparticles: effect of size, dispersion medium and particle surface charge. Phylogeography and post-glacial recolonization in wolverines (Gulo gulo) from across their circumpolar distribution. Is it multiple myeloma or monoclonal gammopathy of undetermined significance?

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Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults. We present a Monte Carlo approach for training partially observable diffusion processes. Liver failure is a life threatening condition currently treated by palliative measures and, when applicable, organ transplantation. Plasmid determined resistance to quinolones in clinical isolates of Gram-negative bacilli. Expression of protein histidine phosphatase in Escherichia coli, purification, and determination of enzyme activity.

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Enantioselective analysis of the free alcohols revealed that 2-heptanol exhibited opposite configurations in purple and yellow passion fruits. We investigated the specific effect of male sterility on female receptivity in an important pest species, the Mediterranean fruitfly (medfly), in which sterile males are often used for population suppression.

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In order to identify the arginine residue, five arginine residues, which are conserved in all higher-plant and cyanobacterial enzymes but not in enteric bacterial enzymes, were individually converted to alanine by site-directed mutagenesis. Measurement of actual respiratory volume delivered by apparatuses for mechanical ventilation of the lungs We herein present a case report of a liver graft infection by HSV-1 associated with liver failure and encephalitis.

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Partially purified fraction (PPF) antigen from adult Fasciola gigantica for the serodiagnosis of human fascioliasis using Dot-ELISA technique. In addition, enzyme assays, chlorophyll content and light microscopy of leaves were used to characterize acclimation to light-limited growth conditions. Interestingly, we also report increased levels of hyaluronidases in patients with IPF and IPF with PH.

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An assessment was made of the clinical usefulness of the repeat Pap smear. Mi-1 intron 1 flanking primers were designed to amplify intron 1 and fingerprint Mi-1 homologs. Both conditions show nail deformities, focal palmoplantar keratoderma, and follicular hyperkeratoses. Neural stem cells are retained in the postnatal subventricular zone (SVZ), a specialized neurogenic niche with unique cytoarchitecture and cell-cell contacts. For feature detection, early cueing increased activation in the right MFG and late cueing increased activation in the bilateral precuneus (PCu), right TPJ, and right cuneus.

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Autoantibodies revealed: the role of B cells in autoimmune disease. Systematic assessment of surgical complications in laparoscopically assisted vaginal hysterectomy for pelvic organ prolapse. Thanks to the availability of an emergency unit specifically dedicated to out-patients with hematologic diseases, selected out-hospital management of AML patients during post-consolidation cytopenia is a feasible, well accepted and cost-saving option, and can contribute to lower the risk of developing severe nosocomial infections.

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Aneuploidy assessed by DNA index influences the effect of iron status on plasma and/or supernatant cytokine levels and progression of cells through the cell cycle in a mouse model. The potential value of the seaweed Ceylon moss (Gelidium amansii) as an alternative bioenergy resource. In sum, the present study demonstrates that marital dissatisfaction, conflict over child rearing, and early adolescent adjustment difficulties are interwoven in a dynamic family system marked by reciprocity along these dimensions. These methods are applicable to various texture patterns in dermatoscopy images, including patterns that lack fine lines such as cobblestone, follicular, or thickened network patterns. This short review summarizes the experimental and clinical evidence regarding the role of cardiac troponin in assessment of cardiac function, in following findings: neonatal intensive care, respiratory distress syndrome, asphyxia, congenital heart disease and post cardiac surgery.

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Systemic and coronary hemodynamic effects of intracoronary administration of prostaglandins E1 and E2. Eighty-six VCFs in 47 patients (35 female and 12 male) were treated during 55 kyphoplasty procedures.

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We describe the development of marked dilutional acidosis as a complication of management of right ventricular myocardial infarction. Nevertheless, the signaling mechanisms underlying Mn toxicity are unknown.

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Analysis of all 18 possible single point mutations in the -10 consensus sequence reveals that binding by Bacillus subtilis Esigma(A)holoenzyme depends critically upon adenine at position -11 and, unexpectedly, is strongly affected by substitutions of the poorly conserved adenines at -9 and -8. Bomb residue contains material which would localize in bones if it entered the body, and much of it has a long radioactive and biological half-life.

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Deletion of SIR4 rescued the expression defect of 26 of 37 telomere-proximal genes with reduced expression in set2Delta cells, implying that H3-K36 methylation prevents the spread of telomeric silencing. We examined whether supplementation with the omega-3 fatty acid eicosapentaenoic acid (EPA)-modified 5-HT amplified ADP-induced platelet aggregation in patients with schizophrenia.

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Internal consistency and factor analysis of the Dutch version of the Dizziness Handicap Inventory. Previously, we have determined the X-ray crystal structure of PlyC, revealing a complicated and unique arrangement of nine proteins. This may influence the reliability of the test as a physiologic measure of acid reflux.

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The wave function of a hole bound to an individual Mn acceptor in GaAs is spatially mapped by scanning tunneling microscopy at room temperature and an anisotropic, crosslike shape is observed. The results show that the proposed method can robustly infer patterns from partially annotated images with low computational cost.

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Above onset wheel-driven ripples move in the direction of motion of the wheel, but plow-driven ripples move in the reverse direction for a narrow range of Froude numbers. This review summarizes the status of zebrafish as a genetic model to study human hematological disorders. Apocynin reduced the NFkappaB activation at 1 h of reoxygenation. Several classes of linear mixed models evaluated whether cognitive decline increased per additional year closer to death.

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Two patients showed molecular cytogenetic results which were compatible with non-contiguous chromosome 1 euchromatin. To estimate the prevalence of hepatitis B virus and C virus infections and their genotypes and analyze the risk factors for the markers of exposure to hepatitis B virus in female sex workers in a region of intense sex trade. Immunoblotting analysis, promoter assay and electrophoretic mobility shift assay showed that Fkn upregulated hypoxia-inducible factor-1 alpha (HIF-1alpha) by cultured human aortic endothelial cells (ECs), which in turn induced mRNA and protein levels of vascular endothelial growth factor (VEGF)-A through a p42/44 mitogen-activated protein kinase pathway. A kinetic assay for phenylalanine hydroxylase based on measurement of oxygen consumption in described. Antenatal ultrasound showed left diaphragmatic hernia and polyhydramnios.

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Of interest, there is no enthalpic signal for binding of folate fragments such as dihydrobiopterin where the p-aminobenzoylglutamate tail has been removed, pointing to the tail as providing most of the enthalpic signal. To date, 143 human cases, including 45 deaths, have been recorded. When the non-infective epimastigote stage of the parasite was transfected with a vector containing the gp82 gene, an 82 kDa surface glycoprotein, which was indistinguishable from the metacyclic stage protein, was expressed. Single-molecule magnets of ferrous cubes: structurally controlled magnetic anisotropy.

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Access to treatment for opioid dependence in rural America: challenges and future directions. We hypothesize that there is a threshold in the nuclear NFAT concentration above which MCIP is imavir acyclovir and alcohol switched on.

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Molecular incivek fda label basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3). Dental caries was diagnosed according to the criteria recommended by the World Health Organization (1997). While supersalts are found to be stable, the ability of superalkalis to form as the core of hyperhalogens is limited due to their large size. This study identifies ATM as a potential target for the treatment of HK.

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We report here a synthetic route to oxime, azide and nitrone-bearing copolymers via reversible addition-fragmentation chain transfer copolymerization of 4-vinylbenzaldehyde and 1-(chloromethyl)-4-vinylbenzene with styrene. The absence of peripheral eosinophilia does not exclude eosinophilic cardiac nozer sheriar reviews of bio involvement. Compare BDNF levels in depressed patients and healthy controls in platelet poor plasma and in washed platelets. Use of functional MR increases importantly the posttest probabilities of hemispheric language dominance in multiple subgroups of individuals with and without epilepsy.

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Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers. Furthermore, the organizer coordinates morphogenetic movements, and zebrafish mutants in T-box mesoderm-specific genes help clarify the mechanism of convergence movements required for the formation of axial and paraxial mesoderm. Toxicity profile, quality of life (QOL), and pharmacoeconomic evaluations maraviroc dosing darunavir resistance were evaluated as well. In the control group (C), a suture line was passed around the left anterior descending coronary artery (LADCA). To investigate the social determinants of HIV serostatus for these two high-risk populations.

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Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts. Dihydrogenation of flavones to flavanones increased the ocular blood flow further. Photographs of the constellation Cygnus taken in the daytime from altitudes above 100 kilometers indicate that the day sky brightness in the wave-length region from 3600 to 7000 angstroms is only slightly brighter than the night sky viewed from the ground. These data provide normative values that topiramate weight loss 75 mg benadryl can be used in clinical practice.

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The relationship between doxepin doses available of adderall sex ratio in population incidence and expected relative risk (RR) to first-degree relatives of probands of the low risk sex vs the high risk sex under the Multifactorial-Polygenic Model was examined. Generalized electrocortical activation by cortical stimulation in the cat. The first is the benign or low-grade malignant tumours, well-differentiated, called typical carcinoids (TC) and the second is the high-grade malignant tumours, poorly differentiated of small (SCLC) or large cell type (LCLC). Moreover, even a single taxon can have a powerful effect upon biogeographic interpretations.