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Topigen (Topiramate)

Topigen is an oral drug that is used to prevent the seizures of epilepsy. It is an anti-epileptic or anti-seizure drug. It is used primarily among patients who are not controlled by other anti-epileptic drugs. About 1 in 4 Americans diagnosed with epilepsy has seizures that resist treatment with other anti-epileptic drugs. Topigen also prevents migraine headaches. Seizures are due to the abnormal activity ("firing") of nerves in the brain, and the abnormal activity spreads to smaller or larger portions of the brain. Although Topigen's exact mechanism of action is unknown, scientific studies suggest that it may alter neurotransmitters within the brain. Neurotransmitters are chemicals that nerves manufacture and use to communicate with other nearby nerves. By altering the production or action of the neurotransmitters, Topigen may suppress the abnormal activity of the nerves in the brain that cause the seizures or may prevent the abnormal activity from spreading to other nerves. Other studies suggest that Topigen may suppress the nerves directly (i.e., not by altering neurotransmitters) and make them less likely to fire. The FDA approved Topigen as a tablet in 1997. The sprinkle capsules were approved in October 1998.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Medullary and extramedullary hematopoiesis in the dog after whole body irradiation and transfusion with stem cells obtained from blood Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL) and is also associated with a variety of lymphocyte-mediated diseases. Treatment of RA with pharmacological agents that interfere with antigen-driven T cell proliferation has been more successful. Effects of a sedative and a convulsant barbiturate on synaptosomal calcium transport.

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Because T3 response elements and LXREs have similar configurations, referred to as direct repeat 4, we investigated the possibility of cross-talk between the two ligand-dependent signal transduction pathways. Future concerns will need to concentrate on the use of better methods for gene insertion and homologous recombination techniques for the development of animal models and later as a strategy for gene therapy. In recent years, we have developed segmented-type STEM detectors which divide the detector plane into 16 segments and enable simultaneous imaging of 16 STEM images which are sensitive to the positions and angles of transmitted/scattered electrons on the detector plane. We did this because we previously showed that replacement of saturated fats by trans fats in a controlled diet decreased FMD after 4 weeks.

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The increase in the number of deaths occurred due to the increase in population and its aging. Delayed gastric emptying was identified in IBS and in some patients may contribute to at least a component of their symptoms.

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Between December 2002 and December 2004, 60 patients with a diagnosis of chronic gastroesophageal reflux disease scheduled for laparoscopic Nissen fundoplication were recruited prospectively and volunteered to participate in this study. Monoubiquitination of histone H2B lysine 123 regulates methylation of histone H3 lysine 4 (H3K4) and 79 (H3K79) and the lack of H2B ubiquitination in Saccharomyces cerevisiae coincides with metacaspase-dependent apoptosis. Level of concern was highly associated with parental education and parenting style. We present two unusual cases in which an eyelid tumor was the first sign of metastatic disease.

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The findings of this study provide potential targets for future preventive and public health interventions. Other techniques, developed in Japan, include the application of different types of knife such as the insulated-tip instrument.

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If validated in larger cohorts, lenalidomide rather than azacitidine should be considered for first-line therapy after ESA treatment failure. HEREDITARY PHOTOMYOCLONUS ASSOCIATED WITH DIABETES MELLITUS, DEAFNESS, NEPHROPATHY, AND CEREBRAL DYSFUNCTION. Thirty-three consecutive patients with advanced NSCLC that had been pretreated with at least one chemotherapeutic regimen and were responding to chemotherapy following 2 to 3 cycles of treatment, entered the trial from May 2004 to February 2006. Affinity proteomics, represented by recombinant antibody arrays, is a novel, multiplex technology for high-throughput protein expression profiling of crude serum proteomes in a highly specific, sensitive, and miniaturized manner.

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SCOT mRNA was expressed in MKN-45, MKN-74 and normal fibroblasts, but not in MKN-28 or OCUM-2M. Prompt surgical intervention may improve the prognosis in patients with NE.

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Nanocolloidal gold-based immunoassay for the detection of the N-methylcarbamate pesticide carbofuran. Hydrogen bonding, both intra- and intermolecular, seems to be a decisive factor determining the inhibitor attachments.

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A mixed method design was used consisting of a postal survey and in-depth qualitative interviews with a subset of questionnaire respondents. The influence of adrenergic activation and blockade on the motility of the circular and longitudinal muscle layers of the rabbit oviduct in vitro. In the 1980s, attempts were made to use placenta-eluted gamma globulins (PEGG) in patients with graft-versus-host disease (GVHD) after bone marrow transplantation (BMT). These changes were greater in the tibialis as compared to soleus and diaphragm. Using neuroimaging, we examined brain responses to rectal distension in adolescent IBS patients, focusing on determining the alteration of salience network integrity in IBS and its functional implications in current theoretical frameworks.

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We demonstrate that the anisotropic displacement parameters directly visualize the underlying mobility between the two domains, and present a detailed structural analysis of the packing of the residues, including the critical alpha4 helix, that comprise the interface. The clinical physician in relation to the progress in neuropsychopharmacology

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An ideal biomarker would be identifiable before lesion development. Accuracy and precision of EyeSys and Orbscan systems on calibrated spherical test surfaces. However, these associations were not statistically significant for those with no resection.

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Relationship of hepatitis C virus infection with diabetes in the U.S. THE USE OF A SODIUM HYPOSULFITE SOLUTION AFTER THE SCHILLER TEST Confounded by sequencing depth in association studies of rare alleles. These structures were elucidated on the basis of spectroscopic analysis.

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The results of both comparative studies show that the UKF provides a higher accuracy than the EKF due to the limited ability of EKF to accurately estimate the mean and covariance matrix of the estimated states through lineralization of the nonlinear process model. Kinetic study of the oxidation of gamma-L-glutaminyl-4-hydroxybenzene catalyzed by mushroom (Agaricus bisporus) tyrosinase. Plasma samples taken at various times during OLT from 15 patients and 15 healthy controls were spiked with 1 g L(-1) fibrinogen concentrate or saline.

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It was difficult to obtain clear images of the endothelial cell layer postdissection, possibly because of tissue swelling or distortion. Specifically, we hypothesized that processing focusing on shape differences would be associated with projector synesthetes, while processing focusing on ordinality or familiarity would be associated with associator synesthetes.

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Treatment is somewhat empirical, given that uncertainties remain in our understanding of the pathophysiology of this vascular complication, which involves structural and biochemical changes in the endothelium and smooth muscle of vessels. Many of the known TA pairs interact as proteins, but recent work has identified a new class of antitoxins that are RNA cleavage products.

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In contrast to lung structure damage, skeletal muscle retains regenerative capacity in COPD. Under these conditions, myoglobin provides a measurable increase in O2 transport for supply PO2 below 10 Torr and diffusion lengths expected for skeletal muscle fibers. The frequent DNA losses at 6q and 13q suggest that the presence of tumor suppressor genes at these regions is important in NK cell transformation. Proliferative and functional activity in the liver of the normal and precancerous rat

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Prognosis has not improved in decades, despite the advent of improved antimicrobial therapy and heightened index of suspicion among clinicians caring for affected infants. Here we introduce the first full genome of a pure culture within the genus Dehalobacter. In this article, we provide an overview of this novel SDCT technology in abdominal imaging. Studies were identified using MEDLINE and Embase, the references of identified studies, international experts on CS clearance and authors of primary studies. However, the addition of noise and the decrease of luminance contrast decreased the visibility of motion comparably.

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Data were analyzed with four-way ANOVA and Tukey post hoc tests. Audiovisual integration (AVI) has been demonstrated to play a major role in speech comprehension.

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Early involvement of a dedicated ophthalmologist is recommended to secure an early detection of a visual decline and potential tumour recurrence. Complete bony union was obtained in all cases at 3 to 6 weeks postoperatively. Role of mutations identified in ORFs M56 (terminase), M70 (primase) and M98 (endonuclease) in the temperature-sensitive phenotype of murine cytomegalovirus mutant tsm5. In patients with diabetes, management of hypertension is frequently complicated by the coexistence of other macrovascular risk factors, including dyslipidemia, obesity, visceral adiposity, and poor glycemic control. Biochemical and genetic characterization of the pathways for trehalose metabolism in Propionibacterium freudenreichii, and their role in stress response.

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Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Progression of brain damage after status epilepticus and its association with epileptogenesis: a quantitative MRI study in a rat model of temporal lobe epilepsy. Recent studies from animal models and clinical trials suggest promising effects of this method in treating patients with IBD, but more studies are urgently needed to confirm its efficacy and safety, since the etiology of this chronic inflammatory disease is not fully understood and caution should be taken when transplanting fecal matters between individuals which might transfer other infectious organisms and diseases.

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We report the case of a 51-year-old female with poorly differentiated bladder carcinoma who presented with leukocytosis and hypercalcemia. Interestingly, RXR has been shown to enhance the LXR transactivation, even in the absence of LXR ligand via a unique mechanism of allosteric regulation.

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In biological samples the resonant coherent anti-Stokes Raman scattering signal of less abundant constituents can be overwhelmed by the nonresonant background, preventing detection of those molecules. Correlation between the degree of duodenal bulbar deformity and the density of Helicobacter pylori infection in patients with active duodenal ulcers. Fragile X syndrome neurobiology translates into rational therapy. In contrast to PlyG, however, the 1.6 A X-ray crystal structure of PlyB(cat) reveals that the catalytic domain adopts the glycosyl hydrolase (GH)-25, rather than phage T7 lysozyme-like fold. The objective of the study was to investigate the temporal and spatial appearance of Ob-Rb in the human digestive tract and leptin in the stomach.

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High-capacity adenoviral vectors for gene transfer and somatic gene therapy. Therefore, it may reduce the duration of mechanical ventilation in selected patients. Pigs were vaccinated with an attenuated Japanese encephalitis virus (JEV) vaccine and challenged with virulent JEV, either by subcutaneous injection or by exposure to infected mosquitoes. Recent advances in the fields of biomaterials, biomimetics, and tissue engineering have focused attention on the potentials for clinical application.

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Energy-gaining formation and catalytic behavior of active structures in a SiO(2)-supported unsaturated Ru complex catalyst for alkene epoxidation by DFT calculations. The results showed that diabetic mice exhibited a significant behavioral deficit, including depression-like behavior in forced swim test, anxiety-like in open field test and sociability deficits in social interaction test, along with a significant decrease in serotonin level in these brain regions. Group 1, which included 104 studies, was used to develop the measurement method (i.e., the formulas) for measuring left and right atrial volumes from a nonenhanced study. By contrast, adhesion receptor signalling through platelet endothelial cell adhesion molecule 1 (PECAM-1) is implicated in the inhibition of platelet function and thrombus formation in the healthy circulation. However, the rgdA gene affected brlA and abaA expression, which function as key regulators of asexual sporulation, suggesting that rgdA functions upstream of those genes.

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The temporal and spatial expression of Claudins in epidermal development and the accelerated program of epidermal differentiation in K14-CaSR transgenic mice. A brief, intense flash of mode-locked laser light pulses excites fluorescent molecules via multiphoton excitation in an ellipsoidal focal volume and photobleaches a fraction.

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Prevalence of hypothyroidism (HT) markedly differs among various populations. We find the IC process to occur a few tens of femtoseconds after excitation. The telephone mode resulted in a higher response rate than the postal mode and fewer men than women participated in the postal methylcatechol glucuronide tadalafil dosage mode. OHIP scores were calculated in three ways: a simple count method, an additive method and a method incorporating item weights derived from the Thurstone paired comparison technique. The effects of various drugs, including thalidomide, all-trans retinoic acid, dexamethasone, IFN-alpha and incadronate, on the MIC expression and NK cell cytotoxicity were examined.

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Evaluation of point-of-care maternal venous lactate testing risperidone dosage for adults in normal pregnancy. Discontinuation of fentanyl administration resulted in a time-dependent elevation of brain reward thresholds and somatic withdrawal signs. The underlying cause of the epidermal acanthosis in psoriasis is still largely unknown. This is useful for generating singlet oxygen for photodynamic therapy, creating a long lasting reactive species for catalysis and for extending diffusion lengths in photovoltaic applications while retaining three molecular modification points for further functionalization. In the children, MP-RAGE was useful for cases of partial anomalous pulmonary venous drainage, particularly in the evaluation of abnormal pulmonary veins.

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This has the advantage that the image acquisition time is limited by the maximum exposure time and that regulation of the illuminating light level is not required. The present study aimed to capture the subjective experience of older people who had recently made a suicide attempt through exploring their understanding of the pathway to and from this attempt, within the context of ageing. Using recombinant retroviruses, we acutely transduced neonatal foreskin keratinocytes (PHKs) with a lacZ reporter gene driven by the wild-type URR of the low-risk HPV type 11 or by a URR with individual mutations in seven promoter-proximal elements, some of which have not been characterized previously. Using an anchored and nested RT-PCR strategy, combined with circular RACE-PCR, the full length sequence of the chicken MT cDNA was obtained. Since rat heart possesses primarily type A and mouse heart primarily type B MAO, these results suggest that some local anesthetics have a preferential action on one apo lansoprazole vs prevacid generic form of the enzyme while others have a preferential action on the other.

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Association between alcohol calorie intake and overweight buspirone hydrochloride 30 mg get you high and obesity in English adults. Vascular endothelial growth factor receptors: expression and function in solid tumors. To assess whether the risk of medically attended local reactions to the fifth dose of the diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine varies according to injection site (arm versus thigh). Postoperative radiotherapy is often combined in case of invasive thymoma invading into adjacent organs. The educational session aroused a great interest from the participants.

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These findings indicate that higher stress and lower social status increase risk of smoking, but that stress does not explain the naproxen and esomeprazole magnesium with silica association between lower social status and smoking. For exploration of human IgA responses, we have designed a duplexing antisense constant region primer that efficiently amplifies, side-by-side, heavy chain transcripts of both the IgA1 and IgA2 subclasses. We have found that, along with LAT, 2B4 is constitutively located in glycolipid-enriched microdomains of the plasma membrane. Herpes simplex virus infection in young infants during 2 decades of empiric acyclovir therapy.

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