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Xenalon (Spironolactone)

Xenalon is a synthetic 17-Xenalon corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Xenalon competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for active clinical trials using this agent.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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The protective effect of zinc on rosin and resin acid toxicity in human polymorphonuclear leukocytes and human gingival fibroblasts in vitro. To overcome limitations in identifying tapeworms of the genus Taenia by traditional approaches, we have established a single-strand conformation polymorphism (SSCP) method utilizing two different regions of mitochondrial (mt) DNA as targets. Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain.

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The present study describes developmental changes in autonomic controls of heart rate in a strain of rats genetically predisposed to hypertension (spontaneously hypertensive rats or SHR) and in a normotensive strain of rats (Wistar-Kyoto rats or WKY). Some lessons learned from using medium scale genotyping techniques in pharmacogenetic research. Glass microelectrodes were used to record transmembrane electrical activity from cells located just beneath the endocardial surface of segments from the atrial and right ventricular free walls of rat hearts during superfusion and electrical stimulation in vitro at 37 degrees C.

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The structure of the binary CH(3)-H(4)folate/MeTr complex (revealed here) lacks any obvious proton donor near the N5 group. Implication of reactive oxygen species in the antibacterial activity against Salmonella typhimurium of hepatocyte cell lines. Specific nucleotide derivatives alone did not affect the growth of healthy peripheral blood mononuclear cells. The findings suggest that mast cell prostaglandins are an important factor in the pathogenesis of pruritus and that local vascular responses may trigger mast cell degranulation.

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Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98. Association of the polymorphisms in the gene encoding thyroglobulin with the development and prognosis of autoimmune thyroid disease.

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A number of immunotherapeutic cancer vaccines appear likely to be registered soon and these will be dependent for efficacy upon new adjuvant formulations. Left ventricular (LV) dysfunction can occur after hyperkalemic cardioplegic arrest and subsequent reperfusion and rewarming. A proportion of patients report increased pruritus, but other short-term markers of quality of life are unaffected.

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DNA samples were collected retrospectively from 145 Danes infected with HIV-1 with known seroconversion times. Health economics provides such a framework and it is suggested that those working in pharmacoepidemiology might make more of this framework in seeking to address essential trade-offs and inform policy.

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The mechanisms of the plasma lipid alterations and the current guidelines for their management in the elderly are presented. Cloning vectors and fluorescent proteins can significantly inhibit Salmonella enterica virulence in both epithelial cells and macrophages: implications for bacterial pathogenesis studies.

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Nevertheless, some cyclized CPPs can further enhance cellular uptake and binding selectivity when compared to activities of their linear counterpart, especially when treating chemoresistant tumors. Biochemical and structural characterization of membrane fractions from bovine lens. Receptor-mediated stimulation of brain GTPase by opiates in normal and dependent rats.

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The effect of olive leaf extract in decreasing the expression of two pro-inflammatory cytokines in patients receiving chemotherapy for cancer. Consequences of the new changes in Dutch spelling for the Nederlands Tijdschrift voor Geneeskunde

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Mucosa-associated lymphoid tissue (MALT) type lymphoma has generally been thought not to show increased fluorine 18-fluorodeoxyglucose (FDG) accumulation on positron emission tomography (PET), based on previous research. While the gastrointestinal tract was once regarded simply as a digestive organ, new technologies have led the science world to wonder about the impact that the gut microbiota may have on human health and disease. Predicting posttraumatic epilepsy with MRI: prospective longitudinal morphologic study in adults. Left ventricular function is expected to improve after transcatheter aortic valve implantation due to the acute reduction in afterload, but does not occur in all patients.

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Patient 1 had an erythrocyte sedimentation rate (ESR) of 38 mm/hr and a C-reactive protein (CRP) of 28mg/L. To assess the beneficial and harmful effects of treating viral myocarditis with corticosteroids. Differential diagnosis of such cases includes (cystic) teratoma, epidermal cyst, rectal duplication cyst, anal gland cyst and carcinoma, extension of local carcinoma, and metastatic disease.

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The organic osmolytes betaine and proline are transported by a shared system in early preimplantation mouse embryos. In contrast to Fas-receptor deficient lpr mice, hepatic fibrosis and the inflammatory response was not affected by loss of Bid.

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Stiffness of fatty tissues tissue depended strongly on the connective tissue content. Mechanical compliance was studied in rat small intestine subjected to 48 hours of simple obstruction. Differences in neuronal toxicity and its molecular mechanisms between methamphetamine and methylphenidate Trace metals in PM10 and PM 2.5 samples collected in a highly industrialized chemical/petrochemical area and its urbanized surroundings. Thirdly, we present learning objectives which cover core content for environmentally accountable medical curricula, developed through a reflective process of international collaboration integrating current literature and the workshop outcomes.

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Factors associated with different hygiene practices in the homes of 15 month old infants. A simple steroid trial was conducted to assess whether 31 patients with chronic airflow obstruction would benefit from oral steroid therapy. The cohort effect in incidence rates of femoral fracture has not been previously shown and would be compatible with a number of aetiological hypotheses. Thus VGAT is the first of a new family of neurotransmitter transporters. Diffusion-weighted magnetic resonance imaging (MRI) can detect ischemia within minutes of onset, but its ability to reliably detect hyperacute cerebral hemorrhage is unknown.

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Our past work indicates that growth-inhibiting chondroitin sulfate proteoglycan (CSPG) is abundant in the peripheral nerve sheaths and interstitium. Patients were randomly assigned to receive either conventional IV anesthesia (CON) or general anesthesia combined with thoracic epidural anesthesia followed by postoperative epidural analgesia (TEA) with bupivacaine. The inhibition of the cytotoxicity was pronounced when 5-HT was added at the onset of the cytotoxic assay, whereas the pretreatment of lymphocytes for 18 h only led to a slight inhibition. The source of pituitary cell line did not appear to influence satellite cell ultrastructure.

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In addition, Abf1p binding causes bending of the HIS7 promoter structure. However, postmarketing surveillance has revealed significant hepatotoxicity with trovafloxacin.

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Net joint forces did not explain the differences in cartilage changes. Furthermore, NO-mediated vasodilation was reduced to a greater extent than in controls. Lipoarabinomannan and lipid-free arabinomannan antigens of Mycobacterium paratuberculosis. From a biomechanical point of view, the clinical use of pedicle screws in C1 is a promising alternative to lateral mass screws. We review here the clinical features of cutaneous lupus and recent genetic data that elucidate potential candidate genes for both cutaneous lupus erythematosus (CLE) and SLE.

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Mycorrhized and nonmycorrhized plants of hybrid poplar (Populus tremula L. In an integrated health care system using an EMR, AAA screening can be implemented with a dramatic reduction in unscreened patients. While cultivation is of limited importance in the diagnostic laboratory, it is essential to most research laboratories, and it is toward the latter that this review is primarily aimed.

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The interpretation of serum biochemistry test results in domestic animals. Across all three regimens, Dex administration evoked upregulation of cerebrocortical 5HT1A and 5HT2 receptors and the presynaptic 5HT transporter, greatest for 5HT1A receptors. Barium esophagram: does it have a role in gastroesophageal reflux disease? Body weight, food and water intake, systolic blood pressure, plasma glucose, insulin and lipid were measured.

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Impaired plasmalogen biosynthesis and peroxisomal beta-oxidation due to a deficiency of catalase-containing particles (peroxisomes) in cultured skin fibroblasts. Ventricular contractile function was examined in single isolated left ventricular cardiomyocytes. A number of these antimicrobials, however, have been rendered inactive by resistance mechanisms.

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Outpatients with moderate-to-severe SAHS attending the chest clinic. This study was to identify the prevalence of orthostatic hypotension and its association with risk factors of orthostatic hypotension aged over 60 in Seoul and Chungju, Korea. Metal-insulator-semiconductor structures in a form of Au/SiO(2)/ZnO-nanorod-array were fabricated on Si.

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A total of 25 patients with IgE-mediated anaphylactic food allergy to milk, eggs, or wheat were selected. The aims of this study were: to investigate the referral rates of postlingually deafened adult cochlear implant (CI) candidates from a hearing aid (HA) clinic for a CI candidacy assessment and to gain insight about factors influencing the referral pathways to CI assessments. Exact one-sided confidence bounds for the risk ratio in 2 x 2 tables with structural zero. Antiserum raised against intimin from enterohemorrhagic Escherichia coli (EHEC) O157:H7 strain 86-24 has been shown previously by our laboratory to inhibit adherence of this strain to HEp-2 cells. Ropivacaine produces sensory and motor blockade which is similar to that produced by equal concentrations of bupivacaine after epidural administration in the sheep.

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Nitrite and carboxyhemoglobin in PASMC medium were detected with spectrophotometry. Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton. The emissions of PCDD/Fs, cadmium and lead were greatly enhanced when the polyvinyl chloride was included in the feed waste stream. Nitric oxide (NO) scavengers and sequestration of VEGF and BDNF blunted this induction of tube formation, whereas addition of exogenous NO donor, rBDNF and rVEGF rescued the induction of tube formation.

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Leukocyte trafficking is critically regulated by chemokines and their receptors. Electronic spectroscopy of toluene-rare-gas clusters: the external heavy atom effect and vibrational predissociation. The participants were 120 people with MS who were ambulatory from a population-based sample. Study 3 showed that MS increased the search for meaning for low, but not high, trait self-esteem individuals.

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Correlations were sought between these characteristics and modal values of latitude, aridity and continentality in the geographic range of each species. In order to test this hypothesis this study evaluated the capacity of pretreatment with the 5-HT(2) receptor antagonist ritanserin to attenuate the effects of the 5-HT agonist, m-chlorophenylpiperazine (mCPP). Two single-arm phase II studies were carried out in adults with GBM. This case represents a unique variant of myelodysplastic syndrome, best described as sideroblastic myelodysplasia.

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Several independent risk factors were found to predict the requirement for MV in patients with GBS at admission. Overall, our results demonstrate that dedifferentiated blastemal cells formed at the initial phase of limb regeneration must enter the nerve-dependent epimorphic phase for further processes, including blastema outgrowth, and that failure of entry results in a simple redifferentiation as tissue regeneration. Benefits of retroequatorial four horizontal muscle recession surgery in congenital idiopathic nystagmus in adults. The penicillin treatment of acrodermatitis atrophicans chronica.

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As expected with this large cohort spanning over 18 years, there was loss-to-follow-up. A nine-year institutional experience with near-total laryngectomy. Compared with other members of the GST family, GSTA1 displays surprisingly little variation.

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These new radiometric calibration methods provide good technique experiences for the next generation in-flight optical sensors. Exogenous GDNF increased astrocytic migration in gdnf gene-deleted tissue cultures, comparable to lengths observed in wildtype tissue cultures. In addition, delivery of vaccine antigens directly within heat-inactivated yeast cells is attractive due to the adjuvancy provided by the yeast cell.

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COMPARISON OF FLAME IONIZATION AND ELECTRON CAPTURE DETECTORS FOR THE GAS CHROMATOGRAPHIC EVALUATION OF HERBICIDE RESIDUES. A newly developed gel centrifugation test for quantification of RBC-bound IgG antibodies and their subclasses IgG1 and IgG3: comparison with flow cytometry.

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It seems that bystander effects may have important clinical implications for health risk after low level radiation exposure of cells lying outside the radiation field during clinical treatment. Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling. Time course of nitric oxide production after endotoxin challenge in mice. Off-pump coronary artery bypass grafting is safe, effective, and associated with reduced morbidity in high-risk patients compared with conventional coronary artery revascularization.

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Testing of CrmBs in the experimental model of LPS-induced shock using SPF BALB/c mice detected a pronounced protective effect of VARV-CrmB. Determination of total chromium in phosphate rocks by ion chromatography. Does the Neighborhood Area of Residence Influence Non-Attendance in an Urban Mammography Screening Program? An Outbreak of Trichinosis in New York City-With Special Reference to the Intradermal and Precipitin Tests.

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In patients with chronic posterolateral knee injuries, failure to correct genu varus alignment will often result in failure of the posterolateral knee repair or reconstruction. Protease digestions of the complexes support this conclusion and show that a global conformation change occurs in ER when bound to the different ER binding sites. Effect of biologically active substances present in water extracts of white mustard and coriander on antioxidant status and lipid peroxidation of mouse C2C12 skeletal muscle cells. These tumors can occur sporadically or as manifestations of genetic syndromes such as neurofibromatosis types 1 and 2 or schwannomatosis. In addition, chromogranin A has a circadian rhythm unrelated to plasma catecholamines.

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Although endotheliocytosis has been reported in birds exposed to PCBs, vascular effects have not been previously described in mammals treated with these compounds. Results can be used for comparison with data from other institutions and surgical facilities. They were randomized into three groups according to dose and route of administration (15 mg/kg intravenously, 15 mg/kg intraperitoneally, or 150 mg/kg intraperitoneally) and then given a single dose of docetaxel.

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Dysfunction of the Bicer val mitral prosthesis--emergency operation with survival Intermediate neurological development of 60 neonates weighing 1500 grams or less at birth. Evaluating the indirect effect of infant weight velocity on insulin resistance in young adulthood: a birth cohort study from the Philippines.

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It is suggested that the hypotensive action of ketanserin in the rat does not involve a central mechanism but a peripheral alpha-adrenolytic action is implicated. VEGF-A gene was overexpressed in both microdissected lymphoma and endothelial cells. Therapy for polycystic liver is invasive, expensive, and has disappointing long-term results. Interestingly, combinations of activating mutations of Crk II with mutations in the highly conserved PNAY sequence in the SH3-C inactivated the activating mutations, suggesting that the SH3-C is necessary for activation. As discussed above, we have proposed a model in which the alpha/beta complex promotes the production of antigenic peptides by opening the exit port of the 20S proteasome (Whitby et al.

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The results of the present study do not indicate that auditory hallucinations and associated abnormal electrophysiological activity are the consequence of atrophy of localized temporal lobe structures. To evaluate the accuracy of pretest probability assessment of PE by physicians in training using the Wells clinical model and to assess the safety of a diagnostic strategy including pretest probability assessment. In those who do not respond, consideration should be given first to day care or in-patient treatment which may be combined with UVB phototherapy. The hepatoprotective action of ursodeoxycholic acid (UDCA) was previously suggested to be partially dependent on its antioxidative effect.

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590 newly diagnosed hypertensive patients presenting at the Cardiology Unit of University of Abuja Teaching Hospital over a three-year period were studied. Detection of Mycobacterium bovis in bovine tissue samples by the Abbott LCx Mycobacterium tuberculosis assay and comparison with culture methods. Burkitt leukemia as the presenting form of acquired immunodeficiency syndrome.

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The aim of this study was to compare the clinical effects of non-surgical periodontal therapy between diabetes mellitus type 2 patients (DM type 2) and non-diabetic individuals (control group). Systemic issues involved in working with professional sports teams. The relationship between local determinants and malaria transmission intensity was investigated using multinomial and ordered logistic models. We sought to determine the frequency of podocyte-related gene mutations in a heterogeneous population of adults and children with biopsy-proven FSGS. RNase E action at a distance: degradation of target mRNAs mediated by an Hfq-binding small RNA in bacteria.

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PLB-985 cells did not express CD132 (gammac) but expressed the complete IL-4 type II receptor (IL-4Ralpha and IL-13Ralpha1). Specimens taken during the procedure were scored for goblet cells, subepithelial thickening, mast cells and eosinophils. We review the characteristics and effects of these inhibitors on inflammatory and other diseases.

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These data suggest that preverbal infants expect a causal agent as the source of motion of an inert object. Serum osteocalcin level and alkaline phosphatase activity was assessed with acute long bone fractures and with delayed bone union and pseudoarthroses. About a quarter of subjects eligible for ART did not complete screening and pre-treatment mortality was very high even though patients in this setting were well informed. We reviewed the clinical data of 100 patients with pyogenic liver abscess who were treated at Seoul and Guri Hanyang University Hospital from 1999 to 2003.

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The phylogenies of previously published mitochondrial control region (or D-loop) DNA sequences in gorillas show deep splits within West African gorillas (Gorilla gorilla gorilla), and very high levels of nucleotide diversity in this subspecies. Together, the results suggest a model in which Ihh coordinates diverse aspects of skeletal morphogenesis through PTHrP-dependent and independent processes. These terms are added as perturbations to the original potential energy, and the attendant changes in the properties of the system are obtained. To describe utilization patterns for anti-diabetes medications among a cohort of diabetes patients in the Military Health System (MHS) before and after warnings about rosiglitazone finasteride 5mg side effects in women issued in May 2007. Risperidone does not affect steady-state pharmacokinetics of divalproex sodium in patients with bipolar disorder.

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Association of four common SNPs in microRNA polymorphisms with the risk of hepatocellular carcinoma. The contractions and the electrical activity were recorded on isolated superfused rat uteri. TFCC lesions and scapholunate dissociation remain to be the most common causes for arthroscopic wrist surgery. In addition, the development of therapy for malignant diseases also requires assays to identify the target leukemic stem cells based on their levoxacin 500 mg cistite acuta ability to initiate the disease.

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Since AMPK has become a critical target for treating diabetes, we cena leku bactrim forte tablets herein investigate the anti-hyperglycemic potential of LOE. Recent studies reveal not only that Id protein expression is significantly correlated both with cancer progression and with overall prognosis, but also that it can be exploited as a therapeutic target.

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In the other two groups, quantitative analysis of TBT and TPhT was carried out, weekly, on the target organs (muscle and liver). beta-CCt (0.3-10.0 mg/kg) and 3-PBC (0.3-17.0 mg/kg) also antagonized the aggression-heightening effects of midazolam (1.0 mg/kg). Gastrointestinal symptoms as well as signs had been a major concern with the use of traditional non-steroidal anti-inflammatory drugs. kofron antibiotics Descriptive cross-sectional study aimed at the management teams and members of the functional units of 31 hospitals in the Madrid Health Service.

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Through analysis of variation and function of 5 main endogenous hormones in the formation of microtuber of Dioscorea opposite in vitro to explore the physiological and biochemical mechanism of microtuber development. Clinical data of 84 patients who underwent stenting in our center from May 2005 to July 2013 were retrospectively analyzed. Nonresponders to hepatitis C virus antiviral therapy: pegylated lansoprazole side effects diarrhea interferons and beyond.

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Large amounts of sugar are present in the woody, nonfood parts of crops and could be used for fuel production ofloxacin pediatric dosing without compromising global food security. Highly active anti-retroviral therapy (HAART) appears to be the most promising treatment to prevent the progression of childhood HIVAN. Illness severity in RCBD generally precludes double-blind controlled investigations.

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It has now been generally accepted that the autoxidation of arachidonic acid occurs in vivo and leads to formation of isoprostanes and other products. Colonic perforation hairlosstalk propecia coupon secondary to taxol therapy: an unusual presentation. Moreover AEN distribution revealed perinuclear staining pattern which could be seen with other apoptotic nucleases. Computed tomography phenotypes in severe, early-onset chronic obstructive pulmonary disease.

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The rate of urea excretion per unit liver weight was significantly decreased compared with pair-fed control rats both during and after thioacetamide treatment. The frequency of the acyclovir overdose child spontaneous action potential was increased by these agents.